ArticleHearing research2007
Manipulating cell cycle regulation in the mature cochlea.
Article in Hearing research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
26 citing papers in PubMed, 55 citations in OpenAlex.
- Advances and challenges in adeno-associated viral inner-ear gene therapy for sensorineural hearing loss.Molecular therapy. Methods & clinical development · 2021Review
- Combinatorial Atoh1 and Gfi1 induction enhances hair cell regeneration in the adult cochlea.Scientific reports · 2020Article
- Practical aspects of inner ear gene delivery for research and clinical applications.Hearing research · 2020Review
- Spatiotemporally controlled overexpression of cyclin D1 triggers generation of supernumerary cells in the postnatal mouse inner ear.Hearing research · 2020Article
- Age-related transcriptome changes in Sox2+ supporting cells in the mouse cochlea.Stem cell research & therapy · 2019Article
- Characterization of Lgr6+ Cells as an Enriched Population of Hair Cell Progenitors Compared to Lgr5+ Cells for Hair Cell Generation in the Neonatal Mouse Cochlea.Frontiers in molecular neuroscience · 2018Article
- Musashi-1 is the candidate of the regulator of hair cell progenitors during inner ear regeneration.BMC neuroscience · 2017Article
- In Vivo Interplay between p27Cell reports · 2017Article
- Role of Wnt and Notch signaling in regulating hair cell regeneration in the cochlea.Frontiers of medicine · 2016Review
- Characterization of Lgr5+ progenitor cell transcriptomes in the apical and basal turns of the mouse cochlea.Oncotarget · 2016Article
- In Vivo Cochlear Hair Cell Generation and Survival by Coactivation of β-Catenin and Atoh1.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- High-throughput screening reveals alsterpaullone, 2-cyanoethyl as a potent p27Kip1 transcriptional inhibitor.PloS one · 2014Article
- Gene therapy for deafness.Gene therapy · 2013Review
- Regeneration of mammalian cochlear and vestibular hair cells through Hes1/Hes5 modulation with siRNA.Hearing research · 2013Article
- A brief history of hair cell regeneration research and speculations on the future.Hearing research · 2013Review
- Understanding the evolution and development of neurosensory transcription factors of the ear to enhance therapeutic translation.Cell and tissue research · 2012Review
- Filling the silent void: genetic therapies for hearing impairment.Genetics research international · 2012Article
- Mature mice lacking Rbl2/p130 gene have supernumerary inner ear hair cells and supporting cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Development of gene therapy for inner ear disease: Using bilateral vestibular hypofunction as a vehicle for translational research.Hearing research · 2011Review
- Variations in shape-sensitive restriction points mirror differences in the regeneration capacities of avian and mammalian ears.PloS one · 2011Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
Sensorineural hearing loss, which is often caused by degeneration of hair cells in the auditory epithelium, is permanent because lost hair cells are not replaced. Several conceptual approaches can be used to place new hair cells in the auditory epithelium. One possibility is to enhance proliferation of non-sensory cells that remain in the deaf ear and induce transdifferentiation of some of these cells into the hair cell phenotype. Several genes, including p27(Kip1), have been shown to regulate proliferation and differentiation in the developing auditory epithelium. The role of p27(Kip1) in the mature ear is not well characterized. We now show that p27(Kip1) is present in the nuclei of non-sensory cells of the mature auditory epithelium. We determined that forced expression of Skp2 using a recombinant adenovirus vector, resulted in presence of BrdU-positive cells in the auditory epithelium. When SKP2 over-expression was combined with forced expression of Atoh1, ectopic hair cells were found in the auditory epithelium in greater numbers than were seen with Atoh1 alone. Skp2 over-expression alone did not result in ectopic hair cells. These findings suggest that the p27(Kip1) protein remains in the mature auditory epithelium and therefore p27(Kip1) can serve as a target for gene manipulation. The data also suggest that induced proliferation, by itself, does not generate new hair cells in the cochlea.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.