ReviewReviews in endocrine & metabolic disorders2007
Deciphering the molecular basis of breast cancer metastasis with mouse models.
Review in Reviews in endocrine & metabolic disorders, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Resveratrol Prevents Breast Cancer Metastasis by Inhibiting Wnt/β-Catenin Pathway-Mediated Epithelial-Mesenchymal Transition.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Comparative Glycoproteomic Analysis of Mouse 4T1 Breast Cancer Model.Current medicinal chemistry · 2025Article
- Efficacy of punarnavine in restraining organ-specific tumour progression in 4T1-induced murine breast tumour model.Inflammopharmacology · 2019Article
- Mesoporous silica nanoparticle delivery of chemically modified siRNA against TWIST1 leads to reduced tumor burden.Nanomedicine : nanotechnology, biology, and medicine · 2015Article
- DEAD-box helicase DP103 defines metastatic potential of human breast cancers.The Journal of clinical investigation · 2014Article
- Longitudinal imaging of cancer cell metastases in two preclinical models: a correlation of noninvasive imaging to histopathology.International journal of molecular imaging · 2014Article
- Interplay of Stem Cell Characteristics, EMT, and Microtentacles in Circulating Breast Tumor Cells.Cancers · 2013Article
- Breast cancer metastasis: issues for the personalization of its prevention and treatment.The American journal of pathology · 2013Review
- MDM2 promotes invasion and metastasis in invasive ductal breast carcinoma by inducing matrix metalloproteinase-9.PloS one · 2013Article
- How can grafted breast cancer models be optimized?Cancer biology & therapy · 2011Review
- α2 integrin as regulator of metastatic potential.Acta pharmacologica Sinica · 2011Article
- Increased expression of P-glycoprotein is associated with doxorubicin chemoresistance in the metastatic 4T1 breast cancer model.The American journal of pathology · 2011Article
- BMI1 cooperates with H-RAS to induce an aggressive breast cancer phenotype with brain metastases.Oncogene · 2009Article
- Imagable 4T1 model for the study of late stage breast cancer.BMC cancer · 2008Article
- Breast tumor microenvironment: proteomics highlights the treatments targeting secretome.Journal of proteome research · 2008Review
- Contributions of integrin-linked kinase to breast cancer metastasis and tumourigenesis.Journal of cellular and molecular medicineReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Breast cancer begins as a localized disease, but has the potential to spread to distant sites within the body. This process--known as metastasis--is the leading cause of death from breast cancer. Whether the ability of cancer cells to metastasize is an intrinsic or acquired feature is currently a topic of considerable debate. Nevertheless, the key cellular events required for metastasis are generally accepted. These include invasion of the surrounding stromal tissue, intravasation, evasion of programmed cell death, arrest within the vasculature at a distant site, extravasation, and establishment and growth within a new microenvironment. The development of mouse models that faithfully mimic critical aspects of human neoplasia has been instrumental in framing our current understanding of multistage carcinogenesis. This review examines the advantages and limitations of existing murine models for mammary carcinogenesis for probing the molecular mechanisms that contribute to metastasis, as well as non-invasive tumor imaging approaches to facilitate these investigations.
Indexed as
Identifiers
17657606What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.