Trial reportPharmaceutical research2007
Low dose lipid formulations: effects on gastric emptying and biliary secretion.
Trial report in Pharmaceutical research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it, 106 citations in OpenAlex.
- Food effects on the formulation, dosing, and administration of cannabidiol (CBD) in humans: A systematic review of clinical studies.Pharmacotherapy · 2021Pooled it
- Enhancing the pharmacokinetics of abiraterone acetate through lipid-based formulations: addressing solubility and food effect challenges.Drug delivery and translational research · 2025Article
- Exploring LIPIDs for their potential to improves bioavailability of lipophilic drugs candidates: A review.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2023Review
- Formulation and processing of solid self-emulsifying drug delivery systems (HME S-SEDDS): A single-step manufacturing process via hot-melt extrusion technology through response surface methodology.International journal of pharmaceutics · 2023Article
- A self-emulsifying omega-3 fatty acids delivery system for enhanced gastro-intestinal absorption in rats.Food science and biotechnology · 2022Article
- Simulation Models for Prediction of Bioavailability of Medicinal Drugs-the Interface Between Experiment and Computation.AAPS PharmSciTech · 2022Review
- Solidification of Self-Emulsifying Drug Delivery Systems as a Novel Approach to the Management of Uncomplicated Malaria.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Review
- Supersaturated-Silica Lipid Hybrids Improve in Vitro Solubilization of Abiraterone Acetate.Pharmaceutical research · 2020Article
- Palm Oil in Lipid-Based Formulations and Drug Delivery Systems.Biomolecules · 2019Review
- Comparisons of in vitro Fick's first law, lipolysis, and in vivo rat models for oral absorption on BCS II drugs in SNEDDS.International journal of nanomedicine · 2019Article
- Lipids in the Stomach - Implications for the Evaluation of Food Effects on Oral Drug Absorption.Pharmaceutical research · 2018Review
- Oral and transdermal drug delivery systems: role of lipid-based lyotropic liquid crystals.Drug design, development and therapy · 2017Review
- Excipient Nanoemulsions for Improving Oral Bioavailability of Bioactives.Nanomaterials (Basel, Switzerland) · 2016Review
- Influence of Food on Paediatric Gastrointestinal Drug Absorption Following Oral Administration: A Review.Children (Basel, Switzerland) · 2015Review
- Formulation and characterization of hydrochlorothiazide solid lipid microparticles based on lipid matrices of Irvingia fat.International journal of pharmaceutical investigation · 2014Article
- Pharmacokinetic aspects and in vitro-in vivo correlation potential for lipid-based formulations.Acta pharmaceutica Sinica. B · 2014Review
- The role of lipid-based nano delivery systems on oral bioavailability enhancement of fenofibrate, a BCS II drug: comparison with fast-release formulations.Journal of nanobiotechnology · 2014Article
- Evaluating the potential of cubosomal nanoparticles for oral delivery of amphotericin B in treating fungal infection.International journal of nanomedicine · 2014Article
- Lipid-based formulations and drug supersaturation: harnessing the unique benefits of the lipid digestion/absorption pathway.Pharmaceutical research · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeFood stimulates changes to gastrointestinal secretion and motility patterns, however, the effect of smaller quantities of lipid, such as that contained in a lipid-based drug formulation, has not been detailed. This study aimed to examine the effects of small quantities of lipid on gastric emptying and biliary secretion.
methodsThe influence of oral administration of three lipid-based formulations and a negative control formulation on gastric emptying and biliary secretion was evaluated in 16 healthy male subjects using gamma scintigraphy, ultrasonography and duodenal aspiration.
resultsLow quantities (2 g) of long chain lipid stimulated gall bladder contraction and elevated intestinal bile salt, phospholipid and cholesterol levels. Changes in gastric emptying were also evident, although these did not reach statistical significance. Administration of a similar quantity of medium chain lipid, however, had little effect on gastric emptying and gallbladder contraction and did not stimulate appreciable increases in intestinal concentrations of biliary-derived lipids.
conclusionsThe quantities of long chain lipid that might be administered in a pharmaceutical formulation stimulate gallbladder contraction and elevate intestinal levels of bile salt and phospholipid. This effect is a likely contributor to the ability of lipid based formulations to enhance the absorption of poorly water-soluble drugs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.