ArticleThe Journal of membrane biology2007
Organizational principles of the connexin-related brain transcriptome.
Article in The Journal of membrane biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 45 citations in OpenAlex.
- Transcriptomic Challenges We Faced with Animal Models for Neurological Disorders.Current issues in molecular biology · 2026Review
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- Powerful quantifiers for cancer transcriptomics.World journal of clinical oncology · 2020Review
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- GAP junctional communication in brain secondary organizers.Development, growth & differentiation · 2016Review
- Gap junction modulation and its implications for heart function.Frontiers in physiology · 2014Review
- Prenatal corticosteroids modify glutamatergic and GABAergic synapse genomic fabric: insights from a novel animal model of infantile spasms.Journal of neuroendocrinology · 2013Review
- Transcriptome profiling of hippocampal CA1 after early-life seizure-induced preconditioning may elucidate new genetic therapies for epilepsy.The European journal of neuroscience · 2013Article
- The connexin43-dependent transcriptome during brain development: importance of genetic background.Brain research · 2012Article
- Vesicular and conductive mechanisms of nucleotide release.Purinergic signalling · 2012Review
- Gap junctions.Comprehensive Physiology · 2012Review
- Plasticity of the myelination genomic fabric.Molecular genetics and genomics : MGG · 2012Article
- The role of neuronal connexins 36 and 45 in shaping spontaneous firing patterns in the developing retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Sex-dependent gene regulatory networks of the heart rhythm.Functional & integrative genomics · 2010Article
- Connexins, pannexins, innexins: novel roles of "hemi-channels".Pflugers Archiv : European journal of physiology · 2009Review
- Trifluoroethanol reveals helical propensity at analogous positions in cytoplasmic domains of three connexins.Biopolymers · 2009Article
- Glial connexins and gap junctions in CNS inflammation and disease.Journal of neurochemistry · 2008Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
We have found that deletion of genes encoding the gap junction proteins Cx43, Cx32 and Cx36 alter the expression levels of large numbers of genes in mouse brain located on all chromosomes and encoding proteins from all major functional categories. Gene regulation in Cx32 and Cx43 null brains was more similar than that in the Cx36 null brain, suggesting the possibility of transcriptomic controls exerted by both genes on both astrocytes and oligodendrocytes. In order to explore the nature of expression linkage among the genes, we examined coordinated expression patterns in wild-type and connexin null brains. Coordination with Cx43 in wild-type brain predicted regulation in Cx43 nulls with considerable accuracy. Moreover, interlinkage within gene networks was greatly perturbed in the Cx43 null brain. These findings suggest several principles regarding regulatory transcriptomic networks involving gap junction genes and raise the issue of the underlying cause of connexin null phenotypes as well as mechanisms of regulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.