Analysis of the obesity gene FTO in 14,803 type 1 diabetes cases and controls.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

22 citing papers in PubMed, 1 synthesis or guideline pooled it.

1. Impact of FTO genotypes on BMI and weight in polycystic ovary syndrome: a systematic review and meta-analysis.Diabetologia · 2012
   Pooled it
2. 'Fat mass and obesity associated' gene (FTO): no significant association of variant rs9939609 with weight loss in a lifestyle intervention and lipid metabolism markers in German obese children and adolescents.BMC medical genetics · 2008
   Trial
3. The role of mGenes & diseases · 2024
   Review
4. Paternal and maternal obesity but not gestational weight gain is associated with type 1 diabetes.International journal of epidemiology · 2018
   Article
5. Genetic association of FTO/IRX region with obesity and overweight in the Polish population.PloS one · 2017
   Article
6. Many obesity-associated SNPs strongly associate with DNA methylation changes at proximal promoters and enhancers.Genome medicine · 2015
   Article
7. Polymorphism of the FTO Gene Influences Body Weight in Children with Type 1 Diabetes without Severe Obesity.International journal of endocrinology · 2014
   Article
8. Allelic polymorphism detected in the bovine FTO gene.Molecular biotechnology · 2011
   Article
9. The Common FTO Genetic Polymorphism rs9939609 is Associated with Increased BMI in Type 1 Diabetes but not with Diabetic Nephropathy.Biomarker insights · 2010
   Article
10. No association of multiple type 2 diabetes loci with type 1 diabetes.Diabetologia · 2009
    Article
11. Type 1 and type 2 diabetes-chalk and cheese?Diabetologia · 2009
    Article
12. Association of hypoxia inducible factor-1 alpha gene polymorphism with both type 1 and type 2 diabetes in a Caucasian (Hungarian) sample.BMC medical genetics · 2009
    Article
13. Genome-wide association studies in type 1 diabetes.Current diabetes reports · 2009
    Review
14. Gene variants influencing measures of inflammation or predisposing to autoimmune and inflammatory diseases are not associated with the risk of type 2 diabetes.Diabetologia · 2008
    Article
15. FTO gene associated fatness in relation to body fat distribution and metabolic traits throughout a broad range of fatness.PloS one · 2008
    Article
16. FTO gene SNPs associated with extreme obesity in cases, controls and extremely discordant sister pairs.BMC medical genetics · 2008
    Article
17. The FTO gene, implicated in human obesity, is found only in vertebrates and marine algae.Journal of molecular evolution · 2008
    Article
18. Variations in the FTO gene are associated with severe obesity in the Japanese.Journal of human genetics · 2008
    Article
19. Comment on: Gale EAM (2007) To boldly go -- or to go too boldly? The accelerator hypothesis revisited. Diabetologia 50:1571-1575 -- a reply to the editor.Diabetologia · 2007
    Article
20. To boldly go--or to go too boldly? The accelerator hypothesis revisited.Diabetologia · 2007
    Article

Corrections and comments

• Comment on
  A high weight gain early in life is associated with an increased risk of type 1 (insulin-dependent) diabetes mellitus.1994

Authors and funding

5 authors.

Funding

Abstract

PubMed holds no abstract for this paper.

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