ArticleJournal of applied physiology (Bethesda, Md. : 1985)2007
Genetic and environmental influences on skeletal muscle phenotypes as a function of age and sex in large, multigenerational families of African heritage.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
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- Novel approach to assess sarcopenia in children with inflammatory bowel disease.Frontiers in pediatrics · 2024Article
- Polygenic Models Partially Predict Muscle Size and Strength but Not Low Muscle Mass in Older Women.Genes · 2022Article
- Identification of a Novel Locus for Gait Speed Decline With Aging: The Long Life Family Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- The Role of Autophagy in Skeletal Muscle Diseases.Frontiers in physiology · 2021Review
- Masticatory muscle function affects the pathological conditions of dentofacial deformities.The Japanese dental science review · 2020Review
- Muscle-Bone Crosstalk: Emerging Opportunities for Novel Therapeutic Approaches to Treat Musculoskeletal Pathologies.Biomedicines · 2017Review
- Endocrine crosstalk between muscle and bone.Current osteoporosis reports · 2014Review
- Vitamin E in sarcopenia: current evidences on its role in prevention and treatment.Oxidative medicine and cellular longevity · 2014Review
- Menstrual cycle changes in mate preferences for cues associated with genetic quality: the moderating role of mate value.Evolutionary psychology : an international journal of evolutionary approaches to psychology and behavior · 2013Article
- Genetic inheritance effects on endurance and muscle strength: an update.Sports medicine (Auckland, N.Z.) · 2012Review
- Sarcopenia, dynapenia, and the impact of advancing age on human skeletal muscle size and strength; a quantitative review.Frontiers in physiology · 2012Article
- Molecular genetic studies of gene identification for sarcopenia.Human genetics · 2012Review
- ACTN3 R577X Polymorphism and Neuromuscular Response to Resistance Training.Journal of sports science & medicine · 2011Article
- Bivariate genome-wide linkage analysis of femoral bone traits and leg lean mass: Framingham study.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2009Article
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Abstract
The aim of this study was to estimate the heritability of and environmental contributions to skeletal muscle phenotypes (appendicular lean mass and calf muscle cross-sectional area) in subjects of African descent and to determine whether heritability estimates are impacted by sex or age. Body composition was measured by dual-energy X-ray absorptiometry and computed tomography in 444 men and women aged 18 yr and older (mean: 43 yr) from eight large, multigenerational Afro-Caribbean families (family size range: 21-112). Using quantitative genetic methods, we estimated heritability and the association of anthropometric, lifestyle, and medical variables with skeletal muscle phenotypes. In the overall group, we estimated the heritability of lean mass and calf muscle cross-sectional area (h(2) = 0.18-0.23, P < 0.01) and contribution of environmental factors to these phenotypes (r(2) = 0.27-0.55, P < 0.05). In our age-specific analysis, the heritability of leg lean mass was lower in older vs. younger individuals (h(2) = 0.05 vs. 0.23, respectively, P = 0.1). Sex was a significant covariate in our models (P < 0.001), although sex-specific differences in heritability varied depending on the lean mass phenotype analyzed. High genetic correlations (rho(G) = 0.69-0.81; P < 0.01) between different lean mass measures suggest these traits share a large proportion of genetic components. Our results demonstrate the heritability of skeletal muscle traits in individuals of African heritage and that heritability may differ as a function of sex and age. As the loss of skeletal muscle mass is related to metabolic abnormalities, disability, and mortality in older individuals, further research is warranted to identify specific genetic loci that contribute to these traits in general and in a sex- and age-specific manner.
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