ArticleProtein science : a publication of the Protein Society2007
The structure of receptor-associated protein (RAP).
Article in Protein science : a publication of the Protein Society, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Integrative structural analysis of the human LRP2-LRPAP1 complex reveals multiple regulatory sites.Communications biology · 2026Article
- Receptor-associated protein impairs ligand binding to megalin and megalin-dependent endocytic flux in proximal tubule cells.American journal of physiology. Renal physiology · 2023Article
- Proteolytic regulation of a galectin-3/Lrp1 axis controls osteoclast-mediated bone resorption.The Journal of cell biology · 2023Article
- Revealing Angiopep-2/LRP1 Molecular Interaction for Optimal Delivery to Glioblastoma (GBM).Molecules (Basel, Switzerland) · 2022Article
- PhoX: An IMAC-Enrichable Cross-Linking Reagent.ACS central science · 2019Article
- Identification of Receptor Ligands in Apo B100 Reveals Potential Functional Domains.The protein journal · 2018Article
- Voltage-gated calcium channel αF1000Research · 2018Review
- Recombinant Expression of the Full-length Ectodomain of LDL Receptor-related Protein 1 (LRP1) Unravels pH-dependent Conformational Changes and the Stoichiometry of Binding with Receptor-associated Protein (RAP).The Journal of biological chemistry · 2017Article
- Evidence That Factor VIII Forms a Bivalent Complex with the Low Density Lipoprotein (LDL) Receptor-related Protein 1 (LRP1): IDENTIFICATION OF CLUSTER IV ON LRP1 AS THE MAJOR BINDING SITE.The Journal of biological chemistry · 2016Article
- High Affinity Binding of the Receptor-associated Protein D1D2 Domains with the Low Density Lipoprotein Receptor-related Protein (LRP1) Involves Bivalent Complex Formation: CRITICAL ROLES OF LYSINES 60 AND 191.The Journal of biological chemistry · 2016Article
- Structure of the minimal interface between ApoE and LRP.Journal of molecular biology · 2010Article
- Receptor-associated protein interacts with amyloid-beta peptide and promotes its cellular uptake.The Journal of biological chemistry · 2009Article
- Receptor-associated protein (RAP) has two high-affinity binding sites for the low-density lipoprotein receptor-related protein (LRP): consequences for the chaperone functions of RAP.The Biochemical journal · 2009Article
- Activated protein C ligation of ApoER2 (LRP8) causes Dab1-dependent signaling in U937 cells.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- LDL receptor-related protein 1: unique tissue-specific functions revealed by selective gene knockout studies.Physiological reviews · 2008Review
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Authors and funding
9 authors at 6 institutions in 1 country.
Funding
Abstract
The receptor-associated protein (RAP) is a molecular chaperone that binds tightly to certain newly synthesized LDL receptor family members in the endoplasmic reticulum (ER) and facilitates their delivery to the Golgi. We have adopted a divide-and-conquer strategy to solve the structures of the individual domains of RAP using NMR spectroscopy. We present here the newly determined structure of domain 2. Based on this structure and the structures of domains 1 and 3, which were solved previously, we utilized experimental small-angle neutron scattering (SANS) data and a novel simulated annealing protocol to characterize the overall structure of RAP. The results reveal that RAP adopts a unique structural architecture consisting of three independent three-helix bundles that are connected by long and flexible linkers. The flexible linkers and the quasi-repetitive structural architecture may allow RAP to adopt various possible conformations when interacting with the LDL receptors, which are also made of repetitive substructure units.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.