ArticleThe Biochemical journal2007
The zinc finger transcription factor ZFHX1A is linked to cell proliferation by Rb-E2F1.
Article in The Biochemical journal, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- Zeb1 Facilitates Nitrogen Mustard-Induced Corneal Epithelial Wound Healing by Maintaining Epithelial Renewability.Investigative ophthalmology & visual science · 2025Article
- The transcriptional factor ZEB1 represses Syndecan 1 expression in prostate cancer.Scientific reports · 2018Article
- Modeling Developmental and Tumorigenic Aspects of Trilateral Retinoblastoma via Human Embryonic Stem Cells.Stem cell reports · 2017Article
- ZEB1 Regulates Multiple Oncogenic Components Involved in Uveal Melanoma Progression.Scientific reports · 2017Article
- Porphyromonas gingivalis initiates a mesenchymal-like transition through ZEB1 in gingival epithelial cells.Cellular microbiology · 2016Article
- An Rb1-dependent amplification loop between Ets1 and Zeb1 is evident in thymocyte differentiation and invasive lung adenocarcinoma.BMC molecular biology · 2015Article
- The ZEB1 transcription factor acts in a negative feedback loop with miR200 downstream of Ras and Rb1 to regulate Bmi1 expression.The Journal of biological chemistry · 2014Article
- The EMT activator ZEB1 promotes tumor growth and determines differential response to chemotherapy in mantle cell lymphoma.Cell death and differentiation · 2014Article
- Control of glutamine metabolism by the tumor suppressor Rb.Oncogene · 2014Article
- Sequential inductions of the ZEB1 transcription factor caused by mutation of Rb and then Ras proteins are required for tumor initiation and progression.The Journal of biological chemistry · 2013Article
- Molecular basis for viral selective replication in cancer cells: activation of CDK2 by adenovirus-induced cyclin E.PloS one · 2013Article
- EMT-activating transcription factors in cancer: beyond EMT and tumor invasiveness.Cellular and molecular life sciences : CMLS · 2012Review
- miR-200c is upregulated by oxidative stress and induces endothelial cell apoptosis and senescence via ZEB1 inhibition.Cell death and differentiation · 2011Article
- Expanding roles of ZEB factors in tumorigenesis and tumor progression.American journal of cancer research · 2011Article
- Androgen Receptor Regulates Transcription of the ZEB1 Transcription Factor.International journal of endocrinology · 2011Article
- A survey of well conserved families of C2H2 zinc-finger genes in Daphnia.BMC genomics · 2010Article
- Zeb1 represses Mitf and regulates pigment synthesis, cell proliferation, and epithelial morphology.Investigative ophthalmology & visual science · 2009Article
- Epigenetic control of mammalian LINE-1 retrotransposon by retinoblastoma proteins.Mutation research · 2009Article
- Mouse fibroblasts lacking RB1 function form spheres and undergo reprogramming to a cancer stem cell phenotype.Cell stem cell · 2009Article
- Expression of the ZEB1 (deltaEF1) transcription factor in human: additional insights.Molecular and cellular biochemistry · 2008Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
ZFHX1A is expressed in proliferating cells in the developing embryo, and in the present study we provide evidence that its expression is confined to proliferating cells through dependence on the Rb (retinoblastoma protein) family/E2F cell cycle pathway. Mutation of the Rb or E2F1 genes lead to induction of ZFHX1A mRNA, implying that the Rb-E2F1 repressor complex is important for repression of ZFHX1A. This repression is associated with recruitment of an E2F-Rb-histone deacetylase repressor complex to the promoter. A dominant-negative form of E2F1 inhibited ZFHX1A expression in p16INK4a- cells where Rb is constitutively hyperphosphorylated and inactive, suggesting that E2F can contribute to ZFHX1A transactivation in the absence of functional Rb. ZFHX1A is an E-box-binding transcription factor whose binding sites overlap with those bound by Snail1 and 2, and ZFHX1B/SIP1 (leading to at least partially overlapping function; for example, each of the proteins can repress E-cadherin expression). We found that expression of Snail1 and ZFHX1B/SIP1 is also regulated by E2Fs, but in contrast with ZFHX1A this regulation is Rb-family-independent. Snail2 expression was unaffected by either E2F or the Rb family. We propose that the differential effects of the Rb family/E2F pathway on expression of these E-box-binding proteins are important in maintaining their distinct patterns (and thus distinct functions) during embryogenesis.
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