ReviewCellular and molecular neurobiology2008
Agmatine and imidazoline receptors: their role in opioid analgesia, tolerance and dependence.
Review in Cellular and molecular neurobiology, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 60 citations in OpenAlex.
- Contribution of Nischarin/IRAS in CNS development, injury and diseases.Journal of advanced research · 2023Review
- Gut microbial molecules in behavioural and neurodegenerative conditions.Nature reviews. Neuroscience · 2020Review
- Insights into the MnInternational journal of molecular sciences · 2020Article
- Cannabinoids and agmatine as potential therapeutic alternatives for cisplatin-induced peripheral neuropathy.Journal of experimental pharmacology · 2018Review
- Combined Interactions with IACS medicinal chemistry letters · 2016Article
- Imidazoleacetic acid-ribotide in vestibulo-sympathetic pathway neurons.Experimental brain research · 2016Article
- Agmatine Protects Against 6-OHDA-Induced Apoptosis, and ERK and Akt/GSK Disruption in SH-SY5Y Cells.Cellular and molecular neurobiology · 2016Article
- The role of the arginine metabolome in pain: implications for sickle cell disease.Journal of pain research · 2016Review
- Protective effects of agmatine against D-galactosamine and lipopolysaccharide-induced fulminant hepatic failure in mice.Inflammopharmacology · 2014Article
- Generation and primary phenotypes of imidazoline receptor antisera-selected (IRAS) knockout mice.CNS neuroscience & therapeutics · 2013Article
- Changes of imidazoline receptors in spontaneously hypertensive rats.International journal of experimental pathology · 2013Article
- Imidazoleacetic acid-ribotide induces depression of synaptic responses in hippocampus through activation of imidazoline receptors.Journal of neurophysiology · 2011Article
- Analgesic efficacy of CR4056, a novel imidazoline-2 receptor ligand, in rat models of inflammatory and neuropathic pain.Journal of pain research · 2011Article
- Anatomical observations of the caudal vestibulo-sympathetic pathway.Journal of vestibular research : equilibrium & orientation · 2011Review
- Recent progress in the research field of neuropharmacology in China.Cellular and molecular neurobiology · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Agmatine is an endogenous amine that is synthesized following the decarboxylation of L-arginine by arginine decarboxylase. Agmatine exists in mammalian brain and has been proposed as a neurotransmitter and/or neurotransmodulator. Agmatine binds to several targets and is considered as an endogenous ligand for imidazoline receptors. This review, mainly based on our research work in the past decade, focused on the modulations by agmatine action on imidazoline receptors to opioid analgesia, tolerance and dependence, and its possible neurochemical mechanisms. We went on to propose that agmatine and imidazoline receptors constitute a novel system of modulating opioid functions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.