ArticleMammalian genome : official journal of the International Mammalian Genome Society2007
Comparative analysis of sequence characteristics of imprinted genes in human, mouse, and cattle.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 45 citations in OpenAlex.
- Uncovering the architecture of selection in twoEvolutionary applications · 2024Article
- Genomic Imprinting in the New Omics Era: A Model for Systems-Level Approaches.Frontiers in genetics · 2022Review
- Length Polymorphism and Methylation Status of UPS29 Minisatellite of theInternational journal of molecular sciences · 2020Article
- Characterization of bovine (Bos taurus) imprinted genes from genomic to amino acid attributes by data mining approaches.PloS one · 2019Article
- Biallelic expression of Tssc4, Nap1l4, Phlda2 and Osbpl5 in adult cattle.Journal of genetics · 2015Article
- Genomic imprinting effects on complex traits in domesticated animal species.Frontiers in genetics · 2015Review
- Epigenetic disorders and altered gene expression after use of Assisted Reproductive Technologies in domestic cattle.Epigenetics · 2014Review
- Research progress in allele-specific expression and its regulatory mechanisms.Journal of applied genetics · 2013Review
- Expression of KCNQ1OT1, CDKN1C, H19, and PLAGL1 and the methylation patterns at the KvDMR1 and H19/IGF2 imprinting control regions is conserved between human and bovine.Journal of biomedical science · 2012Article
- Article
- DNA sequence polymorphisms in a panel of eight candidate bovine imprinted genes and their association with performance traits in Irish Holstein-Friesian cattle.BMC genetics · 2010Article
- Successful computational prediction of novel imprinted genes from epigenomic features.Molecular and cellular biology · 2010Article
- The impact of CpG island on defining transcriptional activation of the mouse L1 retrotransposable elements.PloS one · 2010Article
- Differential decay of parent-of-origin-specific genomic sharing in cystic fibrosis-affected sib pairs maps a paternally imprinted locus to 7q34.European journal of human genetics : EJHG · 2010Article
- A first-stage approximation to identify new imprinted genes through sequence analysis of its coding regions.Comparative and functional genomics · 2009Article
- Characterization of the differentially methylated region of the Impact gene that exhibits Glires-specific imprinting.Genome biology · 2008Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Genomic imprinting is an epigenetic mechanism that results in monoallelic expression of genes depending on parent-of-origin of the allele. Although the conservation of genomic imprinting among mammalian species has been widely reported for many genes, there is accumulating evidence that some genes escape this conservation. Most known imprinted genes have been identified in the mouse and human, with few imprinted genes reported in cattle. Comparative analysis of genomic imprinting across mammalian species would provide a powerful tool for elucidating the mechanisms regulating the unique expression of imprinted genes. In this study we analyzed the imprinting of 22 genes in human, mouse, and cattle and found that in only 11 was imprinting conserved across the three species. In addition, we analyzed the occurrence of the sequence elements CpG islands, C + G content, tandem repeats, and retrotransposable elements in imprinted and in nonimprinted (control) cattle genes. We found that imprinted genes have a higher G + C content and more CpG islands and tandem repeats. Short interspersed nuclear elements (SINEs) were notably fewer in number in imprinted cattle genes compared to control genes, which is in agreement with previous reports for human and mouse imprinted regions. Long interspersed nuclear elements (LINEs) and long terminal repeats (LTRs) were found to be significantly underrepresented in imprinted genes compared to control genes, contrary to reports on human and mouse. Of considerable significance was the finding of highly conserved tandem repeats in nine of the genes imprinted in all three species.
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