ArticleActa histochemica et cytochemica2007
Immunohistochemical analysis of connexin43 expression in infertile human testes.
Article in Acta histochemica et cytochemica, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- Article
- Vitamin K-Dependent γ-Glutamyl Carboxylase in Sertoli Cells Is Essential for Male Fertility in Mice.Molecular and cellular biology · 2021Article
- Aberrant gene expression by Sertoli cells in infertile men with Sertoli cell-only syndrome.PloS one · 2019Article
- Cholesterol: A Gatekeeper of Male Fertility?Frontiers in endocrinology · 2018Review
- Flutamide induces alterations in the cell-cell junction ultrastructure and reduces the expression of Cx43 at the blood-testis barrier with no disturbance in the rat seminiferous tubule morphology.Reproductive biology and endocrinology : RB&E · 2016Article
- Connexin 43 a check-point component of cell proliferation implicated in a wide range of human testis diseases.Cellular and molecular life sciences : CMLS · 2013Review
- A comprehensive review of genetics and genetic testing in azoospermia.Clinics (Sao Paulo, Brazil) · 2013Review
- Testicular connexin 43, a precocious molecular target for the effect of environmental toxicants on male fertility.Spermatogenesis · 2011Article
- Connexin 43 is critical to maintain the homeostasis of the blood-testis barrier via its effects on tight junction reassembly.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Expression of keratinocyte growth factor and its receptor in rat tracheal cartilage: possible involvement in wound healing of the damaged cartilage.Acta histochemica et cytochemica · 2010Article
- Physiological and physiopathological aspects of connexins and communicating gap junctions in spermatogenesis.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2010Review
- Human papillomavirus infection and its possible correlation with p63 expression in cervical cancer in Japan, Mongolia, and Myanmar.Acta histochemica et cytochemica · 2009Article
- In situ detection of methylated DNA by histo endonuclease-linked detection of methylated DNA sites: a new principle of analysis of DNA methylation.Histochemistry and cell biology · 2008Article
- Blood-testis barrier and spermatogenesis: lessons from genetically-modified mice.Asian journal of andrologyReview
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Connexin43 (Cx43) is abundantly expressed in mammalian testes and implicated in the regulation of cell-to-cell interaction between germ cells and Sertoli cells, which is essential to the normal process of spermatogenesis. In the present study, we investigated the relation between Cx43 expression and the degree of spermatogenesis in infertile human testes. Immunohistochemical analysis of Cx43 was performed on testicular biopsies from 29 patients with azoospermia (n=23) and severe oligospermia (n=6), who gave informed consent to this experiment. The degree of testicular spermatogenesis was evaluated by Johnsen score. In the interstitium, immunostaining for Cx43 was localized to some focal parts of plasma membrane between neighboring Leydig cells. In seminiferous tubules with normal spermatogenesis, Cx43 expression was found between Sertoli cells and germ cells. However, Cx43 expression in maturation arrest was decreased and located mainly in the basal compartment of seminiferous tubules. Finally, there was a significant positive correlation between histological score of spermatogenesis and intensity of Cx43 (p=0.0294). These data suggest that the alteration of Cx43 expression may be involved in spermatogenic impairment, and that the communication between Sertoli cells and germ cells through Cx43 may be important for maturation of spermatogenesis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.