SynthesisJournal of perinatology : official journal of the California Perinatal Association2007
Treating hypotension in the preterm infant: when and with what: a critical and systematic review.
Synthesis in Journal of perinatology : official journal of the California Perinatal Association, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03311178 (An International Multicentre Open-label Comparative Therapeutic Exploratory Trial to Investigate the Role of a New Neonatal Formulation of Dobutamine in the Treatment of Haemodynamic Insufficiency in the Immediate Postnatal Period), which is not on this map. Cited by 51 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
An International Multicentre Open-label Comparative Therapeutic Exploratory Trial to Investigate the Role of a New Neonatal Formulation of Dobutamine in the Treatment of Haemodynamic Insufficiency in the Immediate Postnatal Period
Who cites it
51 citing papers in PubMed, 2 syntheses or guidelines pooled it, 140 citations in OpenAlex.
- Pooled it
- Comparative efficacy of volume expansion, inotropes and vasopressors in preterm neonates with probable transitional circulatory instability in the first week of life: a systematic review and network meta-analysis.BMJ paediatrics open · 2024Pooled it
- Hypotension in Preterm Infants (HIP) randomised trial.Archives of disease in childhood. Fetal and neonatal edition · 2021Trial
- Prospective risk factor monitoring reduces intracranial hemorrhage rates in preterm infants.Deutsches Arzteblatt international · 2013Trial
- Use of antihypotensive therapies in extremely preterm infants.Pediatrics · 2013Trial
- Feasibility study of early blood pressure management in extremely preterm infants.The Journal of pediatrics · 2012Trial
- Hemodynamic effects of delayed cord clamping in premature infants.Pediatrics · 2012Trial
- Caring for the smallest hearts: cardiovascular phenotypes and assessment in tiny babies.Pediatric research · 2026Review
- Cerebral Autoregulation and Optimal Blood Pressure from Birth to Surgery in Neonates with Critical Congenital Heart Disease.Pediatric cardiology · 2026Observational
- Use of hydrocortisone in extremely preterm infants: emphasis on those born least mature.Journal of perinatology : official journal of the California Perinatal Association · 2025Review
- Cardiorespiratory interactions during the transitional period in extremely preterm infants: a narrative review.Pediatric research · 2025Review
- Brain age predicted using graph convolutional neural network explains neurodevelopmental trajectory in preterm neonates.European radiology · 2024Article
- Preterm Infants off Positive Pressure Respiratory Support Have a Higher Incidence of Occult Cerebral Hypoxia.The Journal of pediatrics · 2023Observational
- Dopamine or norepinephrine for sepsis-related hypotension in preterm infants: a retrospective cohort study.European journal of pediatrics · 2023Article
- Neonatal fluid overload-ignorance is no longer bliss.Pediatric nephrology (Berlin, Germany) · 2023Review
- Renal versus cerebral saturation trajectories: the perinatal transition in preterm neonates.Pediatric research · 2022Article
- Bioreactance-derived haemodynamic parameters in the transitional phase in preterm neonates: a longitudinal study.Journal of clinical monitoring and computing · 2022Observational
- Baseline Values of Left Ventricular Systolic Function in Preterm Infants With Septic Shock: A Prospective Observational Study.Frontiers in pediatrics · 2022Article
- Maximum vasoactive-inotropic score and mortality in extremely premature, extremely low birth weight infants.Journal of perinatology : official journal of the California Perinatal Association · 2021Observational
- Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelledA very large proportion of extremely preterm infants receive treatments for hypotension. There are, however, marked variations in indications for treatment, and in the interventions used, between neonatal intensive care units and between neonatologists.
methodsWe performed systematic reviews of the literature in order to determine which preterm infants may benefit from treatment with interventions to elevate blood pressure (BP), and which interventions improve clinically important outcomes.
resultsOur review was not able to define a threshold BP that was significantly predictive of a poor outcome, nor whether any interventions for hypotensive infants improved outcomes, nor which interventions were more likely to be beneficial.
conclusionsThere is a distinct lack of prospective research of this issue, which prevents good clinical care. It is possible that a simple BP threshold that indicates the need for therapy does not exist, and other factors, such as the clinical status or systemic blood flow measurements, may be much more informative. Such a paradigm shift will also require careful prospective study.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.