ArticleBritish journal of cancer2007
Systemic inhibition of tumour angiogenesis by endothelial cell-based gene therapy.
Article in British journal of cancer, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed.
- A Promising Frontier in Cancer Therapy - Combining Endothelial Colony Forming Cells, Nanotechnology, and Hyperthermia for Precision Oncology.Stem cell reviews and reports · 2025Article
- Review
- Advances in cell-based delivery of oncolytic viruses as therapy for lung cancer.Molecular therapy. Oncology · 2024Review
- Human Endothelial Colony-Forming Cells.Cold Spring Harbor perspectives in medicine · 2022Article
- Characterization of Blood Outgrowth Endothelial Cells (BOEC) from Porcine Peripheral Blood.Journal of visualized experiments : JoVE · 2022Article
- Therapeutic Potential of Endothelial Colony-Forming Cells in Ischemic Disease: Strategies to Improve their Regenerative Efficacy.International journal of molecular sciences · 2020Review
- Blood Outgrowth Endothelial Cells as a Cellular Carrier for Oncolytic Vesicular Stomatitis Virus Expressing Interferon-β in Preclinical Models of Non-Small Cell Lung Cancer.Translational oncology · 2020Article
- Vascular Wall as Source of Stem Cells Able to Differentiate into Endothelial Cells.Advances in experimental medicine and biology · 2020Review
- Sphingosine-1-Phosphate Receptor 1 Activity Promotes Tumor Growth by Amplifying VEGF-VEGFR2 Angiogenic Signaling.Cell reports · 2019Article
- Generation of an anti-angiogenic endothelial progenitor cell line via endostatin gene transfer.Molecular medicine reports · 2018Article
- Recent Advances in Endothelial Colony Forming Cells Toward Their Use in Clinical Translation.Frontiers in medicine · 2018Review
- Idiopathic systemic capillary leak syndrome (Clarkson disease).The Journal of allergy and clinical immunology · 2017Review
- Activation of ATP-sensitive potassium channels facilitates the function of human endothelial colony-forming cells via CaJournal of cellular and molecular medicine · 2017Article
- Endothelial Expression of Endothelin Receptor A in the Systemic Capillary Leak Syndrome.PloS one · 2015Article
- Article
- Dysfunction of endothelial progenitor cells from smokers and chronic obstructive pulmonary disease patients due to increased DNA damage and senescence.Stem cells (Dayton, Ohio) · 2013Article
- Article
- Establishment of outgrowth endothelial cells from peripheral blood.Nature protocols · 2012Article
- Article
- Non-hematopoietic stem cells as factories for in vivo therapeutic protein production.Gene therapy · 2012Review
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Angiogenesis and post-natal vasculogenesis are two processes involved in the formation of new vessels, and both are essential for tumour growth and metastases. We isolated endothelial cells from human blood mononuclear cells by selective culture. These blood outgrowth cells expressed endothelial cell markers and responded correctly to functional assays. To evaluate the potential of blood outgrowth endothelial cells (BOECs) to construct functional vessels in vivo, NOD-SCID mice were implanted with Lewis lung carcinoma cells subcutaneously (s.c.). Blood outgrowth endothelial cells were then injected through the tail vein. Initial distribution of these cells occurred throughout the lung, liver, spleen, and tumour vessels, but they were only found in the spleen, liver, and tumour tissue 48 h after injection. By day 24, they were mainly found in the tumour vasculature. Tumour vessel counts were also increased in mice receiving BOEC injections as compared to saline injections. We engineered BOECs to deliver an angiogenic inhibitor directly to tumour endothelium by transducing them with the gene for human endostatin. These cells maintained an endothelial phenotype and decreased tumour vascularisation and tumour volume in mice. We conclude that BOECs have the potential for tumour-specific delivery of cancer gene therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.