Trial reportMolecular vision2007
Effect of intraocular surgery and ketamine on aqueous and serum cytokines.
Trial report in Molecular vision, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 36 citations in OpenAlex.
- Ketamine does not inhibit interleukin-6 synthesis in hepatic resections requiring a temporary porto-arterial occlusion (Pringle manoeuvre): a controlled, prospective, randomized, double-blinded study.HPB : the official journal of the International Hepato Pancreato Biliary Association · 2011Trial
- Cystoid macular edema as a predictor for bleb failure after combined XEN45 Gel Stent implantation with phacoemulsification.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026Article
- Association between inflammatory biomarkers and cataracts: validation from the NHANES database and clinical studies.Frontiers in nutrition · 2026Article
- Pro-Fibrotic Role of Interleukin-4 in Influencing Idiopathic Epiretinal Membrane in Cataract Patients: Analysis From Clinical-Experimental Approaches.Translational vision science & technology · 2023Article
- [Pseudophakic cystoid macular edema : Statement of the German Society of Ophthalmology, the German Retina Society and the German Professional Association of Ophthalmologists. Status 22 October 2022].Die Ophthalmologie · 2023Review
- Peripheral inflammatory effects of different interventions for treatment-resistant depression: A systematic review.Neuroscience applied · 2023Review
- Long-Term Variations in Retinal Parameters after Uncomplicated Cataract Surgery.Journal of clinical medicine · 2022Article
- Corneal Endothelial Cell Loss in Glaucoma and Glaucoma Surgery and the Utility of Management with Descemet Membrane Endothelial Keratoplasty (DMEK).Journal of ophthalmology · 2022Review
- [Pseudophakic cystoid macular edema].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2020Article
- Outcome of phacoemulsification in patients with open-angle glaucoma after selective laser trabeculoplasty.PloS one · 2020Article
- Outcome of Descemet stripping automated endothelial keratoplasty in eyes with an Ahmed glaucoma valve.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2017Article
- Severe reactive ischemic posterior segment inflammation in Acanthamoeba keratitis: Case report of a patient with Sjögren's syndrome.Spektrum der Augenheilkunde : Zeitschrift der Osterreichischen Ophthalmologischen Gesellschaft, OOG · 2017Article
- Bevacizumab in vitreous haemorrhage secondary to radiation retinopathy.BMJ case reports · 2014Article
- Serum levels of Th17-related cytokines in Behcet disease patients after cataract surgery.Molecular vision · 2011Article
- [Cataract surgery. Effect on the posterior segment of the eye].Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft · 2010Article
- Apoptosis of lens epithelial cells induced by high concentration of glucose is associated with a decrease in caveolin-1 levels.Molecular vision · 2009Article
- Manifestation of Panuveitis after Intraocular Surgery in a Child with Blau Syndrome.Middle East African journal of ophthalmologyArticle
- IOP Maintenance in SLT-treated Eyes following Subsequent Phacoemulsification and IOL.Journal of current glaucoma practiceReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo determine the effect of intraocular surgery and anesthesia on aqueous and serum cytokines.
methodsPatients undergoing routine cataract surgery under general and local (peribulbar) anesthesia were randomized to those given general anesthetic with and without the use of ketamine and those having local anesthesia. Aqueous and serum levels of cytokines were collected at commencement of surgery and were determined by an immunoassay using multi-analyte biochip array technology at 18 h post-operatively.
resultsAt 18 h postoperative, all patients (37) showed significant and many fold increases in their aqueous levels of interleukin (IL)-1alpha, IL-1beta, IL-4, IL-6, IL-8, vascular endothelial growth factor (VEGF), tumor necrosis factor (TNF)-alpha, interferon (IFN)-gamma, epidermal growth factor (EGF), and monocyte chemotactic protein (MCP)-1. There was little to no increase in IL-2 and IL-10. Significant increases in some cytokines (EGF, IL-6, and IFN-gamma) in the serum were also found (p=0.038). There were no significant differences in aqueous cytokine levels following the use of ketamine or between those patients who had general and local anesthesia (0.11<p<0.97).
conclusionsThere is an aqueous and serum cytokine response following intraocular surgery whether local (peribulbar) or general anesthesia is used. Of the aqueous cytokines measured, three different patterns of responses emerged at 18 h post-cataract surgery; those that were highly increased (IL-8, IL-6, IFN-gamma, and TNF-alpha), medium increase (IL-1beta, VEGF, IL-4, and MCP-1), and those with little to no change (EGF, IL-1alpha, IL-2, and IL-10).
Indexed as
Identifiers
17653058PMC2779146W33758669What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.