ArticleEndocrine pathology2007
Comparative immunohistochemical assessment of craniopharyngioma and related lesions.
Article in Endocrine pathology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Xanthogranuloma of the sellar region: a systematic review.Hormones (Athens, Greece) · 2023Pooled it
- Transformation Versus Ascertainment Bias of a Suprasellar Lesion: A Histopathologic Conundrum of BRAF V600E Positive Papillary Craniopharyngioma Versus Rathke's Cleft Cyst with Squamous Metaplasia: A Systematic Review.Journal of neurological surgery reports · 2025Article
- Comprehensive molecular characterization of craniopharyngiomas using whole transcriptome and spatial transcriptomics approaches.Brain tumor pathology · 2025Article
- Rathke's cleft cyst: From history to molecular genetics.Reviews in endocrine & metabolic disorders · 2025Review
- Rathke cleft cyst with squamous metaplasia and activating mutations of mitogen-activated protein kinase signaling: illustrative case.Journal of neurosurgery. Case lessons · 2025Article
- Sellar xanthogranuloma: A diagnostic challenge.Surgical neurology international · 2022Article
- Giant Sellar Xanthogranuloma after Surgical Treatment of Symptomatic Rathke's Cleft Cyst.Brain tumor research and treatment · 2018Article
- [Rathke cysts, craniopharyngioma, and colloid cysts : What are the differences between these pathologies?]Der Radiologe · 2018Review
- Pituitary xanthogranulomas: clinical features, radiological appearances and post-operative outcomes.Pituitary · 2018Article
- Rathke's Cleft Cyst or Pituitary Apoplexy: A Case Report and Literature Review.Open access Macedonian journal of medical sciences · 2018Article
- Teratoma of the Sellar Region: a Case Report.Endocrine pathology · 2017Article
- Review of xanthomatous lesions of the sella.Brain pathology (Zurich, Switzerland) · 2017Article
- Remarkable Diagnostic Magnetic Resonance Imaging Findings in Sellar Xanthogranuloma: Report of Three First Cases in Latin America.Journal of neurological surgery reports · 2017Article
- Distinct patterns of primary and motile cilia in Rathke's cleft cysts and craniopharyngioma subtypes.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2016Article
- Spontaneous alteration from Rathke's cleft cyst to craniopharyngioma--possible involvement of transformation between these pathologies.Endocrine pathology · 2014Article
- A case of symptomatic Rathke's cyst.BMJ case reports · 2013Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Craniopharyngiomas (CP), Rathke's cleft cysts (RCC), and sellar xanthogranulomas (XG) are closely related lesions. As expression of cytokeratins 8 (CK8) and 20 (CK20) was reported in RCC but not in CP, the present study investigates the reproducibility of immunohistochemical distinction between CP and RCC, attempting to identify the relationship of XG to these lesions. A comparative study of 55 patient specimens (25 CP, 28 RCC, and 2 XG) was analyzed for the histological features of xanthomatous changes and squamous metaplasia, and expression of CK8 and CK20. In the 25 CP cases, xanthomatous changes were seen in 5 (20%), with CK8 reactivity demonstrated in all 25 cases. A prominent xanthomatous component was identified in 13 of 28 RCC (46%), and squamous metaplasia was seen in 11 (39%), 9 of which also contained xanthomatous features. CK8 reactivity was demonstrated in all 28 RCC cases, whereas CK20 was seen only in 9 cases (32%). Of the two cases diagnosed as XG, none contained epithelium, and immunohistochemistry for cytokeratins was not observed. Overall, differential expression of cytokeratins cannot reliably distinguish CP from RCC. Furthermore, expression of CK20 in RCC is generally seen within a background of prominent squamous metaplasia and reactive xanthomatous changes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.