ArticleThe Journal of molecular diagnostics : JMD2007
''Minor'' BCL2 breakpoints in follicular lymphoma: frequency and correlation with grade and disease presentation in 236 cases.
Article in The Journal of molecular diagnostics : JMD, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- High-resolution architecture and partner genes ofBlood advances · 2018Article
- DNA nanomapping using CRISPR-Cas9 as a programmable nanoparticle.Nature communications · 2017Article
- Is There a Role for Minimal Residual Disease Monitoring in Follicular Lymphoma in the Chemo-Immunotherapy Era?Mediterranean journal of hematology and infectious diseases · 2017Review
- Prevalence of BCL-2/J(H) Translocation in Healthy African Americans.Annals of hematology · 2017Article
- Mutations in early follicular lymphoma progenitors are associated with suppressed antigen presentation.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Next-generation surveillance strategies for patients with lymphoma.Future oncology (London, England) · 2015Review
- Risk of follicular lymphoma associated with BCL2 translocations in peripheral blood.Leukemia & lymphoma · 2015Article
- Hierarchy in somatic mutations arising during genomic evolution and progression of follicular lymphoma.Blood · 2013Article
- Mechanism of fragility at BCL2 gene minor breakpoint cluster region during t(14;18) chromosomal translocation.The Journal of biological chemistry · 2012Article
- Demonstration of array-based analysis for highly multiplexed PCR assays application to detection of IGH@-BCL2 translocations in FFPE follicular lymphoma specimens.The Journal of molecular diagnostics : JMD · 2011Article
- Δ-PCR, A Simple Method to Detect Translocations and Insertion/Deletion Mutations.The Journal of molecular diagnostics : JMD · 2011Article
- Gastrointestinal follicular lymphoma: review of the literature.Journal of gastroenterology · 2010Review
- Low stage follicular lymphoma: biologic and clinical characterization according to nodal or extranodal primary origin.The American journal of surgical pathology · 2009Article
- Article
- A novel fusion 5'AFF3/3'BCL2 originated from a t(2;18)(q11.2;q21.33) translocation in follicular lymphoma.Oncogene · 2008Article
- IGH/BCL2 Status Better Predicts Clinico-Pathological Behavior in Primary Splenic Follicular Lymphoma than Histological Grade and Other Molecular Markers.Clinical pathology (Thousand Oaks, Ventura County, Calif.)Article
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Authors and funding
6 authors.
Funding
Abstract
Follicular lymphomas are frequently associated with the t(14;18)(q32;q21). This translocation can be detected by karyotype, polymerase chain reaction (PCR), and fluorescence in situ hybridization (FISH). In addition to the breakpoints currently used for diagnosis located in the major breakpoint region (MBR) and the minor cluster region (mcr), recent studies have reported the existence of other breakpoints (3' BCL2, 5'mcr, and icr). In this study, we examined the frequency of all five breakpoints in 236 cases of follicular lymphomas by real-time PCR analysis. The distribution of breakpoint sites consisted of MBR in 118 cases (50%), mcr in 11 (5%), icr in 32 (13%), 3' BCL2 in 13 (6%), and 5' mcr in three cases (1%). These findings illustrate significantly higher frequency of the icr breakpoint as compared with the more frequently studied mcr. Correlation of breakpoints with histology showed that MBR breakpoints occur more frequently in grade 2 lymphomas (P = 0.042). A majority of the PCR-negative cases (75%) contained an IGH/BCL2 translocation with FISH methods, suggesting the presence of other BCL2 breakpoints. Correlation of breakpoints with survival did not reveal significant differences. Diagnostic laboratories should consider expanding their PCR methods to include other BCL2 breakpoints and correlating with FISH methods when appropriate.
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