ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
Evidence against GABA release from glutamatergic mossy fiber terminals in the developing hippocampus.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 54 citations in OpenAlex.
- Cognitive enrichment improves spatial memory and alters hippocampal synaptic connectivity in a mouse model for early-life stress.Frontiers in cellular neuroscience · 2025Article
- GABABrain structure & function · 2022Article
- Sonic Hedgehog is expressed by hilar mossy cells and regulates cellular survival and neurogenesis in the adult hippocampus.Scientific reports · 2019Article
- Multifaceted circuit functions of adult-born neurons.F1000Research · 2019Review
- A Comparison of Different Slicing Planes in Preservation of Major Hippocampal Pathway Fibers in the Mouse.Frontiers in neuroanatomy · 2017Article
- Few, Activity-Dependent, and Ubiquitous VGLUT1/VGAT Terminals in Rat and Mouse Brain.Frontiers in cellular neuroscience · 2017Article
- Article
- Activation of local inhibitory circuits in the dentate gyrus by adult-born neurons.Hippocampus · 2016Article
- Co-existence of Functionally Different Vesicular Neurotransmitter Transporters.Frontiers in synaptic neuroscience · 2016Review
- Viral and transgenic reporters and genetic analysis of adult neurogenesis.Cold Spring Harbor perspectives in biology · 2015Review
- Dual-transmitter neurons: functional implications of co-release and co-transmission.Current opinion in neurobiology · 2014Review
- Mood regulation. GABA/glutamate co-release controls habenula output and is modified by antidepressant treatment.Science (New York, N.Y.) · 2014Article
- Mixed neurotransmission in the hippocampal mossy fibers.Frontiers in cellular neuroscience · 2013Review
- Is GABA co-released with glutamate from hippocampal mossy fiber terminals?The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- On the g-protein-coupled receptor heteromers and their allosteric receptor-receptor interactions in the central nervous system: focus on their role in pain modulation.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Molecular and functional characterization of GAD67-expressing, newborn granule cells in mouse dentate gyrus.Frontiers in neural circuits · 2013Article
- GABAergic neurons in the preoptic area send direct inhibitory projections to orexin neurons.Frontiers in neural circuits · 2013Article
- Co-release of glutamate and GABA from single, identified mossy fibre giant boutons.The Journal of physiology · 2012Article
- Juvenile mossy fibres: two pipers in the same pub?The Journal of physiology · 2012Article
- GABA and glutamate are not colocalized in mossy fiber terminals of developing rodent hippocampus.Brain research · 2012Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Hippocampal mossy fibers of young rodents have been reported to corelease inhibitory neurotransmitter GABA in addition to excitatory transmitter glutamate. In this study, we aimed at re-evaluating this corelease hypothesis of both inhibitory and excitatory transmitters in the hippocampus. Electrophysiological examination revealed that, in juvenile mice and rats of the two to 3 weeks old, stimulation at the granule cell layer of the dentate gyrus elicited monosynaptic GABAergic IPSCs in CA3 neurons in the presence of ionotropic glutamate receptor (iGluR) blockers, only when rather strong stimuli were given. The group II mGluR agonist (2S,1'R,2'R,3'R)-2-(2,3-dicarboxycyclo-propyl)glycine (DCG-IV), which selectively suppresses transmission at the mossy fiber-CA3 synapse, abolished almost all postsynaptic responses elicited by the weak stimuli, whereas those by strong stimuli were inhibited only slightly. In addition, the minimal stimulation elicited GABAergic IPSCs in neonatal mice of the first postnatal week, whereas these responses are not sensitive to DCG-IV. Immunohistochemical examination revealed that mossy fiber terminals expressed GABA and the GABA-synthesizing enzyme GAD67, although the expression levels were much weaker than those in the inhibitory interneurons. Notably, the expression levels of the vesicular GABA transporter were much lower than those of GABA and GAD67, and almost below detection threshold. These results suggest that mossy fiber synapses are purely glutamatergic and apparent monosynaptic IPSCs so far reported are evoked by costimulation of inhibitory interneurons, at least in young mice and rats. Hippocampal mossy fiber terminals synthesize and store GABA, but have limited ability in vesicular release for GABA in the developing rodents.
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