ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
Behavioral and in vitro correlates of compulsive-like food seeking induced by operant conditioning in Aplysia.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Low-dimensional signatures of neuronal activity associated with long-term operant conditioning in Aplysia.Communications biology · 2025Article
- Convergent effects of peptides on the initiation of feeding motor programs in the molluskJournal of neurophysiology · 2025Article
- Convergent effects of neuropeptides on the feeding central pattern generator ofJournal of neurophysiology · 2022Article
- Specific Plasticity Loci and Their Synergism Mediate Operant Conditioning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Neuronal population activity dynamics reveal a low-dimensional signature of operant learning in Aplysia.Communications biology · 2022Article
- Article
- Dopamine as a Multifunctional Neurotransmitter in Gastropod Molluscs: An Evolutionary Hypothesis.The Biological bulletin · 2020Review
- Computational model of the distributed representation of operant reward memory: combinatoric engagement of intrinsic and synaptic plasticity mechanisms.Learning & memory (Cold Spring Harbor, N.Y.) · 2020Article
- Successful and unsuccessful attempts to swallow in a reducedLearning & memory (Cold Spring Harbor, N.Y.) · 2019Article
- Use of theJournal of neurophysiology · 2017Review
- Robustness, flexibility, and sensitivity in a multifunctional motor control model.Biological cybernetics · 2017Article
- Article
- Article
- Functional magnetic resonance microscopy at single-cell resolution in Aplysia californica.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Functional organization and adaptability of a decision-making network in aplysia.Frontiers in neuroscience · 2012Article
- Classical conditioning analog enhanced acetylcholine responses but reduced excitability of an identified neuron.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Responses of a bursting pacemaker to excitation reveal spatial segregation between bursting and spiking mechanisms.Journal of computational neuroscience · 2011Article
- Power fluctuations in beta and gamma frequencies in rat globus pallidus: association with specific phases of slow oscillations and differential modulation by dopamine D1 and D2 receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Towards a scientific concept of free will as a biological trait: spontaneous actions and decision-making in invertebrates.Proceedings. Biological sciences · 2011Review
- Neural mechanisms of operant conditioning and learning-induced behavioral plasticity in Aplysia.Cellular and molecular life sciences : CMLS · 2011Review
Corrections and comments
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3 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Motivated behaviors comprise appetitive actions whose occurrence results partly from an internally driven incentive to act. Such impulsive behavior can also be regulated by external rewarding stimuli that, through learning processes, can lead to accelerated and seemingly automatic, compulsive-like recurrences of the rewarded act. Here, we explored such behavioral plasticity in Aplysia by analyzing how appetitive reward stimulation in a form of operant conditioning can modify a goal-directed component of the animal's food-seeking behavior. In naive animals, protraction/retraction cycles of the tongue-like radula are expressed sporadically with highly variable interbite intervals. In contrast, animals that were previously given a food-reward stimulus in association with each spontaneous radula bite now expressed movement cycles with an elevated frequency and a stereotyped rhythmic organization. This rate increase and regularization, which was retained for several hours after training, depended on both the reward quality and its contingency because accelerated, stereotyped biting was not induced in animals that had previously received a less-palatable food stimulus or had been subjected to nonassociative reward stimulation. Neuronal correlates of these learning-induced changes were also expressed in the radula motor pattern-generating circuitry of isolated buccal ganglia. In such in vitro preparations, moreover, manipulation of the burst frequency of the bilateral motor pattern-initiating B63 interneurons indicated that the regularization of radula motor pattern generation in contingently trained animals occurred separately from an increase in cycle rate, thereby suggesting independent processes of network plasticity. These data therefore suggest that operant conditioning can induce compulsive-like actions in Aplysia feeding behavior and provide a substrate for a cellular analysis of the underlying mechanisms.
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