ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2007
GABA affinity shapes IPSCs in thalamic nuclei.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 58 citations in OpenAlex.
- Article
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- Shank3 establishes AMPA receptor subunit composition at cerebellar mossy fiber-granule cell synapses and is associated with altered regional microglial morphology.Neurobiology of disease · 2025Article
- Enhanced Synaptic Inhibition in the Dorsolateral Geniculate Nucleus in a Mouse Model of Glaucoma.eNeuro · 2024Article
- Increased pyramidal and VIP neuronal excitability in rat primary auditory cortex directly correlates with tinnitus behaviour.The Journal of physiology · 2023Article
- Hyperammonemia Enhances GABAergic Neurotransmission in Hippocampus: Underlying Mechanisms and Modulation by Extracellular cGMP.Molecular neurobiology · 2022Article
- Regulation of Inhibitory Signaling at the Receptor and Cellular Level; Advances in Our Understanding of GABAergic Neurotransmission and the Mechanisms by Which It Is Disrupted in Epilepsy.Frontiers in synaptic neuroscience · 2022Review
- A neuroactive steroid with a therapeutically interesting constellation of actions at GABANeuropharmacology · 2021Article
- Single Prolonged Stress Reduces Intrinsic Excitability and Excitatory Synaptic Drive Onto Pyramidal Neurons in the Infralimbic Prefrontal Cortex of Adult Male Rats.Frontiers in cellular neuroscience · 2021Article
- Dravet syndrome-associated mutations inBrain communications · 2021Article
- Regulation of GABAInternational journal of molecular sciences · 2020Review
- Effects of GABAFrontiers in molecular neuroscience · 2020Article
- Distinct kinetics of inhibitory currents in thalamocortical neurons that arise from dendritic or axonal origin.PloS one · 2017Article
- Early postnatal switch in GABAA receptor α-subunits in the reticular thalamic nucleus.Journal of neurophysiology · 2016Article
- Hypothalamic feedforward inhibition of thalamocortical network controls arousal and consciousness.Nature neuroscience · 2016Article
- High affinity and low affinity heteromeric nicotinic acetylcholine receptors at central synapses.The Journal of physiology · 2014Review
- T-type Ca2+ channels in absence epilepsy.Pflugers Archiv : European journal of physiology · 2014Review
- GABAA receptor α and γ subunits shape synaptic currents via different mechanisms.The Journal of biological chemistry · 2014Article
- Modulation of short-term plasticity in the corticothalamic circuit by group III metabotropic glutamate receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- The heterogeneity in GABAA receptor-mediated IPSC kinetics reflects heterogeneity of subunit composition among inhibitory and excitatory interneurons in spinal lamina II.Frontiers in cellular neuroscience · 2014Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Precise neural inhibition in thalamocortical circuits is required for the generation of sleep spindles and suppression of hypersynchrony associated with epileptiform activity. Accordingly, the time course of GABA(A) receptor-mediated IPSC events is an important parameter influencing the strength of inhibitory signaling. In the thalamus, two distinct types of IPSC kinetics are observed: thalamocortical relay neurons in the ventrobasal nucleus (VB) exhibit a fast decaying IPSC, whereas neurons in the adjacent reticular nucleus (RTN) display a long-lasting, slowly decaying IPSC. Here, we used patch-clamp electrophysiology and computational modeling to elucidate the basis for IPSC kinetic heterogeneity in the thalamus. Rapid application of GABA to excised membrane patches revealed that decay kinetics were attributable to intrinsic differences in GABA(A) receptor deactivation. Examination of desensitization and gating properties revealed these to be similar in VB and RTN, with the notable lack of fast and long-lasting desensitized states in both cell types. Computational simulations demonstrate that slow GABA binding and unbinding rates could reproduce the characteristic long-lasting IPSCs in RTN cells. These results indicate that within thalamic circuits, a powerful diversity of inhibitory function can result from simple differences in underlying GABA(A) receptor affinity.
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