ArticleProceedings of the National Academy of Sciences of the United States of America2007
Genome sequencing and comparative analysis of Saccharomyces cerevisiae strain YJM789.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 160 papers.
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Who cites it
160 citing papers in PubMed, 254 citations in OpenAlex.
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- Dicentric chromosomes are resolved through breakage and repair at their centromeres.Chromosoma · 2024Article
- From beer to breadboards: yeast as a force for biological innovation.Genome biology · 2024Review
- RNA viruses, M satellites, chromosomal killer genes, and killer/nonkiller phenotypes in the 100-genomes S. cerevisiae strains.G3 (Bethesda, Md.) · 2023Article
- Widespread epistasis among beneficial genetic variants revealed by high-throughput genome editing.Cell genomics · 2023Article
- A widespread inversion polymorphism conserved among Saccharomyces species is caused by recurrent homogenization of a sporulation gene family.PLoS genetics · 2022Article
- Global genomic instability caused by reduced expression of DNA polymerase ε in yeast.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- A role for synaptonemal complex in meiotic mismatch repair.Genetics · 2022Article
- Isolation, characterization, and genome sequencing of a novel chitin deacetylase producingFrontiers in microbiology · 2022Article
- Multipotent antioxidant and antitoxicant potentiality of an indigenous probioticJournal of food science and technology · 2021Article
- Review
- Noncanonical outcomes of break-induced replication produce complex, extremely long-tract gene conversion events in yeast.G3 (Bethesda, Md.) · 2021Article
- The fidelity of DNA replication, particularly on GC-rich templates, is reduced by defects of the Fe-S cluster in DNA polymerase δ.Nucleic acids research · 2021Article
- Fast and inexpensive whole-genome sequencing library preparation from intact yeast cells.G3 (Bethesda, Md.) · 2021Article
100 more citing papers are in PubMed but not listed here.
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Authors and funding
22 authors at 8 institutions in 3 countries.
Funding
Abstract
We sequenced the genome of Saccharomyces cerevisiae strain YJM789, which was derived from a yeast isolated from the lung of an AIDS patient with pneumonia. The strain is used for studies of fungal infections and quantitative genetics because of its extensive phenotypic differences to the laboratory reference strain, including growth at high temperature and deadly virulence in mouse models. Here we show that the approximately 12-Mb genome of YJM789 contains approximately 60,000 SNPs and approximately 6,000 indels with respect to the reference S288c genome, leading to protein polymorphisms with a few known cases of phenotypic changes. Several ORFs are found to be unique to YJM789, some of which might have been acquired through horizontal transfer. Localized regions of high polymorphism density are scattered over the genome, in some cases spanning multiple ORFs and in others concentrated within single genes. The sequence of YJM789 contains clues to pathogenicity and spurs the development of more powerful approaches to dissecting the genetic basis of complex hereditary traits.
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