ArticleMolecular biology of the cell2007
A Bir1p Sli15p kinetochore passenger complex regulates septin organization during anaphase.
Article in Molecular biology of the cell, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- Junctional Localization of Septin 2 Is Required for Organization of Junctional Proteins in Static Endothelial Monolayers.Arteriosclerosis, thrombosis, and vascular biology · 2021Article
- Kinesins relocalize the chromosomal passenger complex to the midzone for spindle disassembly.The Journal of cell biology · 2018Article
- A Functional Link Between Bir1 and theG3 (Bethesda, Md.) · 2017Article
- Chromosome segregation in budding yeast: sister chromatid cohesion and related mechanisms.Genetics · 2014Review
- The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis.Nature reviews. Molecular cell biology · 2012Review
- A prescription for 'stress'--the role of Hsp90 in genome stability and cellular adaptation.Trends in cell biology · 2012Review
- Bub1, Sgo1, and Mps1 mediate a distinct pathway for chromosome biorientation in budding yeast.Molecular biology of the cell · 2011Article
- Chromosome passenger complexes control anaphase duration and spindle elongation via a kinesin-5 brake.The Journal of cell biology · 2011Article
- Phospho-regulation of kinesin-5 during anaphase spindle elongation.Journal of cell science · 2011Article
- Hsp90-Sgt1 and Skp1 target human Mis12 complexes to ensure efficient formation of kinetochore-microtubule binding sites.The Journal of cell biology · 2010Article
- Integrating high-throughput genetic interaction mapping and high-content screening to explore yeast spindle morphogenesis.The Journal of cell biology · 2010Article
- Inferring a transcriptional regulatory network of the cytokinesis-related genes by network component analysis.BMC systems biology · 2009Article
- A link between aurora kinase and Clp1/Cdc14 regulation uncovered by the identification of a fission yeast borealin-like protein.Molecular biology of the cell · 2009Article
- Efficient chromosome biorientation and the tension checkpoint in Saccharomyces cerevisiae both require Bir1.Molecular and cellular biology · 2009Article
- Nbl1p: a Borealin/Dasra/CSC-1-like protein essential for Aurora/Ipl1 complex function and integrity in Saccharomyces cerevisiae.Molecular biology of the cell · 2009Article
- Bir1 is required for the tension checkpoint.Molecular biology of the cell · 2009Article
- Identification of a novel chromosomal passenger complex and its unique localization during cytokinesis in Trypanosoma brucei.PloS one · 2008Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Kinetochore-passenger complexes in metazoans have been proposed to coordinate the segregation of chromosomes in anaphase with the induction of cytokinesis. Passenger protein homologues in the budding yeast Saccharomyces cerevisiae play a critical role early in mitosis, ensuring proper biorientation of kinetochore-microtubule attachments. Our recent work has implicated the passenger protein Bir1p (Survivin) and the inner kinetochore complex centromere binding factor 3 (CBF3) in the regulation of septin dynamics during anaphase. Here, we present data that is consistent with there being multiple passenger protein complexes. Our data show that Bir1p links together a large passenger complex containing Ndc10p, Sli15p (INCENP), and Ipl1p (Aurora B) and that the interaction between Bir1p and Sli15p is specifically involved in regulating septin dynamics during anaphase. Neither conditional alleles nor mutants of BIR1 that disrupt the interaction between Bir1p and Sli15p resulted in mono-attached kinetochores, suggesting that the Bir1p-Sli15p complex functions in anaphase and independently from Sli15p-Ipl1p complexes. We present a model for how discrete passenger complexes coordinate distinct aspects of mitosis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.