ArticleGenome research2007
Unique genes in giant viruses: regular substitution pattern and anomalously short size.
Article in Genome research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 50 citations in OpenAlex.
- Vicennial metagenomic time series unveils evolutionary dynamics of giant viruses in a freshwater ecosystem.Nature communications · 2026Article
- Article
- Gene Transfer Among Viruses Substantially Contributes to Gene Gain of Giant Viruses.Molecular biology and evolution · 2024Article
- RNA Sequencing of Medusavirus Suggests Remodeling of the Host Nuclear Environment at an Early Infection Stage.Microbiology spectrum · 2021Article
- Medusavirus, a Novel Large DNA Virus Discovered from Hot Spring Water.Journal of virology · 2019Article
- Do Viruses Exchange Genes across Superkingdoms of Life?Frontiers in microbiology · 2017Article
- Comparison of a Modern and Fossil Pithovirus Reveals Its Genetic Conservation and Evolution.Genome biology and evolution · 2016Article
- A phylogenomic data-driven exploration of viral origins and evolution.Science advances · 2015Article
- Evolution of Eukaryotic DNA Polymerases via Interaction Between Cells and Large DNA Viruses.Journal of molecular evolution · 2015Article
- Article
- The common ancestor of archaea and eukarya was not an archaeon.Archaea (Vancouver, B.C.) · 2013Review
- Genomics of Megavirus and the elusive fourth domain of Life.Communicative & integrative biology · 2012Article
- Exploring ORFan domains in giant viruses: structure of mimivirus sulfhydryl oxidase R596.PloS one · 2012Article
- Lateral gene exchanges shape the genomes of amoeba-resisting microorganisms.Frontiers in cellular and infection microbiology · 2012Review
- Phycodnavirus potassium ion channel proteins question the virus molecular piracy hypothesis.PloS one · 2012Article
- Mimivirus reveals Mre11/Rad50 fusion proteins with a sporadic distribution in eukaryotes, bacteria, viruses and plasmids.Virology journal · 2011Article
- Two new subfamilies of DNA mismatch repair proteins (MutS) specifically abundant in the marine environment.The ISME journal · 2011Article
- Giant virus with a remarkable complement of genes infects marine zooplankton.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Ten good reasons not to exclude giruses from the evolutionary picture.Nature reviews. Microbiology · 2009Article
- Horizontal gene transfer of an entire metabolic pathway between a eukaryotic alga and its DNA virus.Genome research · 2009Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Large DNA viruses, including giant mimivirus with a 1.2-Mb genome, exhibit numerous orphan genes possessing no database homologs or genes with homologs solely in close members of the same viral family. Due to their solitary nature, the functions and evolutionary origins of those genes remain obscure. We examined sequence features and evolutionary rates of viral family-specific genes in three nucleo-cytoplasmic large DNA virus (NCLDV) lineages. First, we showed that the proportion of family-specific genes does not correlate with sequence divergence rate. Second, position-dependent nucleotide statistics were similar between family-specific genes and the remaining genes in the genome. Third, we showed that the synonymous-to-nonsynonymous substitution ratios in those viruses are at levels comparable to those estimated for vertebrate proteomes. Thus, the vast majority of family-specific genes do not exhibit an accelerated evolutionary rate, and are thus likely to specify functional polypeptides. On the other hand, these family-specific proteins exhibit several distinct properties: (1) they are shorter, (2) they include a larger fraction of predicted transmembrane proteins, and (3) they are enriched in low-complexity sequences. These results suggest that family-specific genes do not correspond to recent horizontal gene transfer. We propose that their characteristic features are the consequences of the specific evolutionary forces shaping the viral gene repertoires in the context of their parasitic lifestyles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.