ArticleNucleic acids research2007
A predicted operon map for Mycobacterium tuberculosis.
Article in Nucleic acids research, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 73 citations in OpenAlex.
- Genetically encoded transcriptional plasticity underlies stress adaptation in Mycobacterium tuberculosis.Nature communications · 2024Article
- Genetically encoded transcriptional plasticity underlies stress adaptation in Mycobacterium tuberculosis.Research square · 2023Article
- Genetically encoded transcriptional plasticity underlies stress adaptation in Mycobacterium tuberculosis.bioRxiv : the preprint server for biology · 2023Article
- Mycobacterial phosphatase PstP regulates global serine threonine phosphorylation and cell division.Scientific reports · 2019Article
- Rv1460, a SufR homologue, is a repressor of the suf operon in Mycobacterium tuberculosis.PloS one · 2018Article
- The transcriptome of Mycobacterium tuberculosis in a lipid-rich dormancy model through RNAseq analysis.Scientific reports · 2017Article
- Probing Ligand Exchange in the P450 Enzyme CYP121 from Mycobacterium tuberculosis: Dynamic Equilibrium of the Distal Heme Ligand as a Function of pH and Temperature.Journal of the American Chemical Society · 2017Article
- A versatile vector for mycobacterial protein production with a functional minimized acetamidase regulon.Protein science : a publication of the Protein Society · 2017Article
- Construction of Mycobacterium tuberculosis cdd knockout and evaluation of invasion and growth in macrophages.Memorias do Instituto Oswaldo Cruz · 2017Article
- Cross-linking of dicyclotyrosine by the cytochrome P450 enzyme CYP121 fromThe Journal of biological chemistry · 2017Article
- The alr-groEL1 operon in Mycobacterium tuberculosis: an interplay of multiple regulatory elements.Scientific reports · 2017Article
- REMap: Operon map of M. tuberculosis based on RNA sequence data.Tuberculosis (Edinburgh, Scotland) · 2016Article
- Integration of Metabolic Modeling with Gene Co-expression Reveals Transcriptionally Programmed Reactions Explaining Robustness in Mycobacterium tuberculosis.Scientific reports · 2016Article
- Mycobacterium tuberculosis folate metabolism and the mechanistic basis for para-aminosalicylic acid susceptibility and resistance.Antimicrobial agents and chemotherapy · 2015Review
- The Psp system of Mycobacterium tuberculosis integrates envelope stress-sensing and envelope-preserving functions.Molecular microbiology · 2015Article
- Integration of heterogeneous molecular networks to unravel gene-regulation in Mycobacterium tuberculosis.BMC systems biology · 2014Article
- Article
- The PhoP-dependent ncRNA Mcr7 modulates the TAT secretion system in Mycobacterium tuberculosis.PLoS pathogens · 2014Article
- WXG100 protein superfamily consists of three subfamilies and exhibits an α-helical C-terminal conserved residue pattern.PloS one · 2014Article
- IpsA, a novel LacI-type regulator, is required for inositol-derived lipid formation in Corynebacteria and Mycobacteria.BMC biology · 2013Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
The prediction of operons in Mycobacterium tuberculosis (MTB) is a first step toward understanding the regulatory network of this pathogen. Here we apply a statistical model using logistic regression to predict operons in MTB. As predictors, our model incorporates intergenic distance and the correlation of gene expression calculated for adjacent gene pairs from over 474 microarray experiments with MTB RNA. We validate our findings with known examples from the literature and experimentation. From this model, we rank each potential operon pair by the strength of evidence for cotranscription, choose a classification threshold with a true positive rate of over 90% at a false positive rate of 9.1%, and use it to construct an operon map for the MTB genome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.