ArticleRNA (New York, N.Y.)2007
VICKZ proteins mediate cell migration via their RNA binding activity.
Article in RNA (New York, N.Y.), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
- Small molecule inhibitor of Igf2bp1 represses Kras and a pro-oncogenic phenotype in cancer cells.RNA biology · 2022Article
- Article
- Extracellular vesicle-dependent effect of RNA-binding protein IGF2BP1 on melanoma metastasis.Oncogene · 2019Article
- IMP1 suppresses breast tumor growth and metastasis through the regulation of its target mRNAs.Oncotarget · 2016Article
- Loss of Stromal IMP1 Promotes a Tumorigenic Microenvironment in the Colon.Molecular cancer research : MCR · 2015Article
- miR-625 suppresses tumour migration and invasion by targeting IGF2BP1 in hepatocellular carcinoma.Oncogene · 2015Article
- The RNA Binding Protein Igf2bp1 Is Required for Zebrafish RGC Axon Outgrowth In Vivo.PloS one · 2015Article
- A Novel Role for VICKZ Proteins in Maintaining Epithelial Integrity during Embryogenesis.PloS one · 2015Article
- RNA-binding protein Vg1RBP regulates terminal arbor formation but not long-range axon navigation in the developing visual system.Developmental neurobiology · 2014Article
- IMP1 promotes tumor growth, dissemination and a tumor-initiating cell phenotype in colorectal cancer cell xenografts.Carcinogenesis · 2013Article
- Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs): post-transcriptional drivers of cancer progression?Cellular and molecular life sciences : CMLS · 2013Review
- Tumour promoting and suppressing roles of the atypical MAP kinase signalling pathway ERK3/4-MK5.Journal of molecular signaling · 2012Article
- IGF2BP1 promotes cell migration by regulating MK5 and PTEN signaling.Genes & development · 2012Article
- ZBP1 recognition of beta-actin zipcode induces RNA looping.Genes & development · 2010Article
- Blocking beta-catenin binding to the ZBP1 promoter represses ZBP1 expression, leading to increased proliferation and migration of metastatic breast-cancer cells.Journal of cell science · 2009Article
- A role for VICKZ proteins in the progression of colorectal carcinomas: regulating lamellipodia formation.The Journal of pathology · 2008Article
- Motility screen identifies Drosophila IGF-II mRNA-binding protein--zipcode-binding protein acting in oogenesis and synaptogenesis.PLoS genetics · 2008Article
- Control of cell migration through mRNA localization and local translation.Wiley interdisciplinary reviews. RNAReview
- IGF2BP1: a post-transcriptional "driver" of tumor cell migration.Cell adhesion & migrationArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The highly conserved, RNA binding VICKZ proteins help regulate RNA localization, stability, and translation in many eukaryotes. These proteins are also required for cell migration in embryos and cultured cells. In adults, many tumors overexpress VICKZ homologs, and it has been hypothesized that the proteins can mediate cell motility and invasion. How these proteins facilitate cell movement and, in particular, whether their ability to bind RNA plays a role in their function remain unclear. Using HPLC and mass spectrometry to identify a region of Xenopus Vg1 RBP (xVICKZ3) that binds the vegetal localization element of Vg1 RNA, we generated a deletion construct that functions in a dominant-negative manner. The construct associates with full-length xVICKZ3 and severely reduces binding to target RNAs. This dominant-negative construct phenocopies the effect of down-regulating xVICKZ3 in Xenopus embryos. A corresponding deletion in the human homolog hVICKZ1 similarly functions in a dominant-negative fashion to reduce the ability of full-length hVICKZ protein to bind RNA. Expression of the dominant-negative construct in human carcinoma cells inhibits cell movement by several criteria. We conclude that the ability of VICKZ proteins to mediate cell migration, in vitro and in vivo, requires their RNA binding activity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.