ArticleVascular pharmacology2007
The effects of estrogen and testosterone on gene expression in the rat mesenteric arteries.
Article in Vascular pharmacology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 15 citations in OpenAlex.
- Progesterone receptor expression in fibromuscular dysplasia: A report of two unusual cases.Turk gogus kalp damar cerrahisi dergisi · 2019Article
- Oestrogen upregulates the sarcoplasmic reticulum Ca(2+) ATPase pump in coronary arteries.Clinical and experimental pharmacology & physiology · 2014Article
- C-fos down-regulation inhibits testosterone-dependent male sexual behavior and the associated learning.The European journal of neuroscience · 2013Article
- Vascular effects of estrogenic menopausal hormone therapy.Reviews on recent clinical trials · 2012Review
- Alterations in vasomotor systems and mechanics of resistance-sized mesenteric arteries from SHR and WKY male rats following in vivo testosterone manipulation.Biology of sex differences · 2012Article
- Gene expression signatures differ with extent of atherosclerosis in monkey iliac artery.Menopause (New York, N.Y.) · 2011Article
- Partial correlation network analyses to detect altered gene interactions in human disease: using preeclampsia as a model.Human genetics · 2011Article
- Two pathways for prostaglandin F2 alpha synthesis by the primate periovulatory follicle.Reproduction (Cambridge, England) · 2008Article
- Estrogens and selective estrogen receptor modulators regulate gene and protein expression in the mesenteric arteries.Vascular pharmacologyArticle
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
A dramatic difference exists in the timing of development of cardiovascular disease in men vs. women. The primary candidates underlying the cause of this gender difference are the sex steroids, estrogen and testosterone. The vasculature is considered to be a site of action of these steroids. In spite of these concepts there is little data on the direct effects of estrogen and testosterone on gene expression in the vasculature. In this study, ovariectomized Sprague Dawley rats were treated for 4 days with vehicle (sesame oil), estradiol benzoate (0.15 mg/kg/day), or testosterone (1 mg/kg/day). The mesenteric arteries were obtained, total RNA was extracted, and CodeLink Uniset Rat I DNA microarrays were used to identify differential gene expression. Seven genes were identified as differentially expressed from the DNA microarray data and confirmed by real time RT-PCR. The expression of D site albumin promoter binding protein and fatty acid synthase were increased in response to both estrogen and testosterone. 3 alpha-hydroxysteroid dehydrogenase, interleukin 4 receptor, JunB and c-Fos expression were increased by estrogen but not by testosterone. Aryl hydrocarbon nuclear translocator-like gene was reduced by testosterone. These data identify genes not previously known to be responsive to estrogen and testosterone in the vasculature.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.