Evidence map›Paper›PMID 17651505›Full record

ReviewRetrovirology2007

Host factors influencing susceptibility to HIV infection and AIDS progression.

Juan Lama, Vicente Planelles

Open access · goldAbstract readReview
In one paragraph

Review in Retrovirology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 144 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Opioid and neuroHIV Comorbidity - Current and Future Perspectives.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2020
    Review
  14. Review
  15. Review
  16. Article
  17. Review
  18. Review
  19. Observational
  20. Article

8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Juan LamaLa Jolla Institute for Molecular Medicine, 4570 Executive Drive, Suite 100, San Diego, California 92121, USA. jlama@retrovirox.com
Vicente Planelles
La Jolla Institute For Molecular Medicine · USUniversity of Utah · US

Funding

INDUCTION OF APOPTOSIS BY HIV-1 VPRR01AI049057 · NIAID · UNIVERSITY OF UTAH · PI PLANELLES, VICENTE · 2000 to 2010
$3.1M
Fusion assay of the HIV-induced CD4 down-modulationR21AI062366 · NIAID · LA JOLLA INST FOR MOLECULAR MEDICINE · PI LAMA, JUAN · 2005 to 2006
$634k
NIAID NIH HHS R01 AI049057NIAID NIH HHS R01 AI49057NIAID NIH HHS R21 AI062366NIAID NIH HHS R21 AI62366
6 · The paper itself

Abstract

Transmission of HIV first results in an acute infection, followed by an apparently asymptomatic period that averages ten years. In the absence of antiretroviral treatment, most patients progress into a generalized immune dysfunction that culminates in death. The length of the asymptomatic period varies, and in rare cases infected individuals never progress to AIDS. Other individuals whose behavioral traits put them at high-risk of HIV transmission, surprisingly appear resistant and never succumb to infection. These unique cases highlight the fact that susceptibility to HIV infection and progression to disease are complex traits modulated by environmental and genetic factors. Recent evidence has indicated that natural variations in host genes can influence the outcome of HIV infection and its transmission. In this review we summarize the available literature on the roles of cellular factors and their genetic variation in modulating HIV infection and disease progression.

Indexed as

Disease SusceptibilityDisease ProgressionGenetic VariationHIV InfectionsHumansImmunity, Innate

Identifiers

PMID17651505
PMCPMC1978541
OpenAlexW2114568178

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.