ArticleBehavioral and brain functions : BBF2007
Association of dopamine receptor polymorphisms with schizophrenia and antipsychotic response in a South Indian population.
Article in Behavioral and brain functions : BBF, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 56 citations in OpenAlex.
- Investigating the association between commonJournal of genetics · 2021Pooled it
- The role of C957T, TaqI and Ser311Cys polymorphisms of the DRD2 gene in schizophrenia: systematic review and meta-analysis.Behavioral and brain functions : BBF · 2016Pooled it
- D2 receptor genetic variation and clinical response to antipsychotic drug treatment: a meta-analysis.The American journal of psychiatry · 2010Pooled it
- Predictive Role of Serotonin Receptor (5HTR2A) and Dopamine Receptor (DRD2) gene polymorphisms in risperidone-induced weight gain and hyperprolactinemia in patients with schizophrenia.European journal of clinical pharmacology · 2025Article
- Dopamine D2 receptor gene Taq 1A polymorphism: genetic architecture in Indian population and comparison to global populations.Frontiers in genetics · 2025Article
- Genetic Testing for Antipsychotic Pharmacotherapy: Bench to Bedside.Behavioral sciences (Basel, Switzerland) · 2021Review
- Association of DRD2 gene polymorphisms with schizophrenia in the young Bangladeshi population: A pilot study.Heliyon · 2020Article
- Association study betweenNeuropsychiatric disease and treatment · 2018Article
- Associations between dopamine D2 receptor gene polymorphisms and schizophrenia risk: a PRISMA compliant meta-analysis.Neuropsychiatric disease and treatment · 2016Article
- Article
- Updated findings of the association and functional studies of DRD2/ANKK1 variants with addictions.Molecular neurobiology · 2015Article
- Association between ANKK1 (rs1800497) and LTA (rs909253) Genetic Variants and Risk of Schizophrenia.BioMed research international · 2015Article
- Genetics of schizophrenia from a clinicial perspective.International review of psychiatry (Abingdon, England) · 2012Review
- Review
- No observable relationship between the 12 genes of nervous system and reasoning skill in a young Chinese Han population.Cellular and molecular neurobiology · 2011Article
- Pharmacogenetics and antipsychotics: therapeutic efficacy and side effects prediction.Expert opinion on drug metabolism & toxicology · 2011Review
- The promise and reality of pharmacogenetics in psychiatry.The Psychiatric clinics of North America · 2010Review
- Research on antipsychotics in India.Indian journal of psychiatry · 2010Article
- The ANKK1 kinase gene and psychiatric disorders.Neurotoxicity research · 2009Article
- A lesson not learned: allele misassignment.Behavioral and brain functions : BBF · 2007Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAlterations in the dopamine transmission and receptor density are hypothesized in the pathophysiology of schizophrenia but ethnic disparities are reported to exist in disease association and therapeutic response to psychotropic medication. Antipsychotics have higher binding affinity to D2 subtype of dopamine receptor. DRD2 Cys311, TaqIB1 and TaqIA1 variants are considered to have either reduced affinity for dopamine and hypo-dopaminergic activity.
methodsWe examined the role of Taq1B, Taq1D, S311C, H313H and Taq1A polymorphisms of DRD2 gene in schizophrenia and antipsychotic treatment response in 213 patients and 196 controls from a homogenous South Indian population. A more detailed genotype phenotype association analysis was carried out to understand the disease in terms of its socio-cultural factors.
resultsH313HTT genotype was found to be associated with schizophrenia (P = 0.004) while TaqIB1B1 genotype was significantly associated with higher psychopathology score. When treatment response was considered H313HCC, TaqIA2A2 and Taq1D1D1 had higher mean improvement scores. TaqID1D1 and H313HTT genotype were found to be significantly higher in responders than in nonresponder group. Distinct shift in the LD patterns of responder and non-responder group was observed. Certain symptoms were characteristic of our patient population. Following medication the scores and presentation of these symptoms tend to vary in the responder and non-responder groups.
conclusionBased on genotype phenotype correlations it can be suggested that certain polymorphisms can be defined for their critical functions in disease and their role in treatment response in South Indian population. The present study suggests that in addition to ethnic bias, socio-cultural factors should also be considered while evaluating genotype phenotype correlations, in association and treatment response to complex disorders like schizophrenia.
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Registered trials
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