ArticleSaline systems2007
Transcriptional profiling of the model Archaeon Halobacterium sp. NRC-1: responses to changes in salinity and temperature.
Article in Saline systems, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed, 98 citations in OpenAlex.
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- Effect of salinity on genes involved in the stress response in mangrove soils.Antonie van Leeuwenhoek · 2023Article
- Saline-Alkali Soil Property Improved by the Synergistic Effects ofInternational journal of molecular sciences · 2023Article
- Genomic Analysis of Haloarchaea from Diverse Environments, including Permian Halite, Reveals Diversity of Ultraviolet Radiation Survival and DNA Photolyase Gene Variants.Microorganisms · 2023Article
- Bioactive molecules from haloarchaea: Scope and prospects for industrial and therapeutic applications.Frontiers in microbiology · 2023Review
- Low Salt Influences Archaellum-Based Motility, Glycerol Metabolism, and Gas Vesicles Biogenesis inMicroorganisms · 2022Article
- Genomic analysis of heavy metal-resistant Halobacterium salinarum isolated from Sfax solar saltern sediments.Extremophiles : life under extreme conditions · 2022Article
- The archaeal classFrontiers in microbiology · 2022Article
- Molecular acclimation ofFrontiers in microbiology · 2022Article
- An archaeal histone-like protein regulates gene expression in response to salt stress.Nucleic acids research · 2021Article
- Revealing the salinity adaptation mechanism in halotolerant bacterium Egicoccus halophilus EGI 80432Applied microbiology and biotechnology · 2021Article
- The Survival ofMicroorganisms · 2021Article
- Genome wide transcriptomic analysis of the soil ammonia oxidizing archaeon Nitrososphaera viennensis upon exposure to copper limitation.The ISME journal · 2020Article
- Extremophilic Microorganisms for the Treatment of Toxic Pollutants in the Environment.Molecules (Basel, Switzerland) · 2020Review
- The Role of Stress Proteins in Haloarchaea and Their Adaptive Response to Environmental Shifts.Biomolecules · 2020Review
- Acid Experimental Evolution of the HaloarchaeonFrontiers in microbiology · 2020Article
- Cross-Stress Adaptation in a Piezophilic and Hyperthermophilic Archaeon From Deep Sea Hydrothermal Vent.Frontiers in microbiology · 2020Article
- Extremophilic models for astrobiology: haloarchaeal survival strategies and pigments for remote sensing.Extremophiles : life under extreme conditions · 2020Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe model halophile Halobacterium sp. NRC-1 was among the first Archaea to be completely sequenced and many post-genomic tools, including whole genome DNA microarrays are now being applied to its analysis. This extremophile displays tolerance to multiple stresses, including high salinity, extreme (non-mesophilic) temperatures, lack of oxygen, and ultraviolet and ionizing radiation.
resultsIn order to study the response of Halobacterium sp. NRC-1 to two common stressors, salinity and temperature, we used whole genome DNA microarrays to assay for changes in gene expression under differential growth conditions. Cultures grown aerobically in rich medium at 42 degrees C were compared to cultures grown at elevated or reduced temperature and high or low salinity. The results obtained were analyzed using a custom database and microarray analysis tools. Growth under salt stress conditions resulted in the modulation of genes coding for many ion transporters, including potassium, phosphate, and iron transporters, as well as some peptide transporters and stress proteins. Growth at cold temperature altered the expression of genes involved in lipid metabolism, buoyant gas vesicles, and cold shock proteins. Heat shock showed induction of several known chaperone genes. The results showed that Halobacterium sp. NRC-1 cells are highly responsive to environmental changes at the level of gene expression.
conclusionTranscriptional profiling showed that Halobacterium sp. NRC-1 is highly responsive to its environment and provided insights into some of the specific responses at the level of gene expression. Responses to changes in salt conditions appear to be designed to minimize the loss of essential ionic species and abate possible toxic effects of others, while exposure to temperature extremes elicit responses to promote protein folding and limit factors responsible for growth inhibition. This work lays the foundation for further bioinformatic and genetic studies which will lead to a more comprehensive understanding of the biology of a model halophilic Archaeon.
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