ReviewExperientia1991
Biological aspects of cytosine methylation in eukaryotic cells.
Review in Experientia, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 90 citations in OpenAlex.
- Microbiome as an Immunological Modifier.Methods in molecular biology (Clifton, N.J.) · 2020Article
- Identification of genes differentially expressed by calorie restriction in the rotifer (Brachionus plicatilis).Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2010Article
- Oligonucleotides suppress PKB/Akt and act as superinductors of apoptosis in human keratinocytes.Nucleic acids research · 2009Article
- Methylation of cytosine at C5 in a CpG sequence context causes a conformational switch of a benzo[a]pyrene diol epoxide-N2-guanine adduct in DNA from a minor groove alignment to intercalation with base displacement.Journal of molecular biology · 2005Article
- DNA from periodontopathogenic bacteria is immunostimulatory for mouse and human immune cells.Infection and immunity · 2003Article
- Synthesis and properties of oligonucleotides containing 5-formyl-2'-deoxycytidine: in vitro DNA polymerase reactions on DNA templates containing 5-formyl-2'-deoxycytidine.Nucleic acids research · 2001Article
- Mechanisms of immune stimulation by bacterial DNA.Springer seminars in immunopathology · 2000Review
- The influence of base sequence on the immunostimulatory properties of DNA.Immunologic research · 1999Review
- Bacterial DNA as an evolutionary conserved ligand signalling danger of infection to immune cells.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 1998Review
- Antibody responses to DNA in normal immunity and aberrant immunity.Clinical and diagnostic laboratory immunology · 1998Review
- Article
- Distribution of 5-methylcytosine-rich regions in the metaphase chromosomes of Vicia faba.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 1996Article
- Silencing of the E-cadherin invasion-suppressor gene by CpG methylation in human carcinomas.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- The effect of histone H1 and DNA methylation on transcription.The Biochemical journal · 1995Article
- DNA methylation during differentiation of a lower eukaryote, Physarum polycephalum.The Biochemical journal · 1994Article
- Unmethylated thyroglobulin promoter may be repressed by methylation of flanking DNA sequences.The Biochemical journal · 1994Article
- Inactive chromatin spreads from a focus of methylation.Molecular and cellular biology · 1993Article
- Enzymic removal of 5-methylcytosine from DNA by a human DNA-glycosylase.Nucleic acids research · 1993Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The existence in eukaryotes of a fifth base, 5-methylcytosine, and of tissue-specific methylation patterns have been known for many years, but except for a general association with inactive genes and chromatin the exact function of this DNA modification has remained elusive. The different hypotheses regarding the role of DNA methylation in regulation of gene expression, chromatin structure, development, and diseases, including cancer are summarized, and the experimental evidence for them is discussed. Structural and functional properties of the eukaryotic DNA cytosine methyltransferase are also reviewed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.