ArticlePediatric nephrology (Berlin, Germany)2007
Outcome of Henoch-Schönlein purpura nephritis treated with long-term immunosuppression.
Article in Pediatric nephrology (Berlin, Germany), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 56 citations in OpenAlex.
- Clinical course and management of children with IgA vasculitis with nephritis.Pediatric nephrology (Berlin, Germany) · 2023Observational
- Comparison of clinical, pathological and long-term renal outcomes of children with Henoch-Schonlein purpura nephritis and IgA nephropathy.International urology and nephrology · 2022Article
- IgA vasculitis with nephritis: update of pathogenesis with clinical implications.Pediatric nephrology (Berlin, Germany) · 2022Review
- IgA vasculitis.Seminars in immunopathology · 2021Review
- Efficacy and safety of low-dose corticosteroid with azathioprine in the treatment of elderly-onset IgA vasculitis with nephritis.BMJ case reports · 2021Article
- Significance of histological crescent formation in patients with IgA vasculitis (Henoch-Schönlein purpura)-related nephritis: a cohort in the adult Chinese population.BMC nephrology · 2018Article
- Azathioprine therapy for steroid-resistant Henoch-Schönlein purpura: a report of 6 cases.Pediatric rheumatology online journal · 2016Article
- Clinicopathological features and prognosis of membranoproliferative-like Henoch-Schönlein purpura nephritis in children.World journal of pediatrics : WJP · 2015Article
- Mycophenolate mofetil plus prednisone for inducing remission of Henoch-Schönlein purpura nephritis: a retrospective study.Journal of Zhejiang University. Science. B · 2015Article
- Comparison between adults and children with Henoch-Schönlein purpura nephritis.Pediatric nephrology (Berlin, Germany) · 2015Article
- Henoch-Schönlein purpura nephritis in children.Nature reviews. Nephrology · 2014Review
- Renal neutrophil gelatinase-associated lipocalin and kidney injury molecule-1 expression in children with acute kidney injury and Henoch-Schönlein purpura nephritis.Experimental and therapeutic medicine · 2014Article
- Methylprednisolone pulse therapy and intravenous cyclophosphamide therapy combined with cocktail therapy in severe pediatric Henoch-Schönlein purpura nephritis patient.CEN case reports · 2013Article
- Efficacy of triptolide for children with moderately severe Henoch-Schönlein purpura nephritis presenting with nephrotic range proteinuria: a prospective and controlled study in China.BioMed research international · 2013Article
- Treatment of children with Henoch-Schönlein purpura nephritis with mycophenolate mofetil.Pediatric nephrology (Berlin, Germany) · 2012Article
- Improved outcome of Henoch-Schonlein purpura nephritis by early intensive treatment.Indian journal of pediatrics · 2012Article
- Partial response to anakinra in life-threatening Henoch-Schönlein purpura: case report.Pediatric rheumatology online journal · 2011Article
- Clinical outcomes in children with Henoch-Schönlein purpura nephritis grade IIIa or IIIb.Pediatric nephrology (Berlin, Germany) · 2011Article
- Early treatment with methylprednisolone pulse therapy combined with tonsillectomy for heavy proteinuric henoch-schönlein purpura nephritis in children.Nephron extra · 2011Article
- Predictors of outcome in Henoch-Schönlein nephritis.Pediatric nephrology (Berlin, Germany) · 2010Article
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4 authors at 1 institution in 1 country.
Funding
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Abstract
This retrospective study investigated the outcome of 27 children (19 male) with Henoch-Schönlein purpura nephritis (HSN) of International Study of Kidney Disease in Children (ISKDC) grade 3b or higher treated with long-term immunosuppressive therapy in a single centre over a 10-year period. The mean age at presentation was 9.7 years. The median estimated glomerular filtration rate (eGFR) was 91.3 ml/min per 1.73 m(2), with the median urine protein creatinine ratio (UP:UC) 556 mg/mmol. The treatment protocol comprised daily steroids and cyclophosphamide for 8-12 weeks followed by azathioprine and a reducing regimen of alternate-day steroids for 8-12 months. After a mean follow-up period of 7 years following presentation, 37% made a complete recovery, 40.7% had persistent proteinuria, 7.4% had persistent proteinuria and were on antihypertensive therapy and 14.8% had progressed to end-stage kidney failure (ESKF). Children with poor outcome were older at presentation (p 0.005), had more crescents (p 0.015) and had heavier proteinuria 6 months post initial biopsy (p 0.023). All of the four children with ESKF had nephrotic range proteinuria and greater than 50% crescents on initial biopsy. Despite long-term immunosuppression, the majority of children with HSN grade 3b or higher will have persistent renal abnormalities on long-term follow-up.
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