ArticleJournal of molecular evolution2007
The VARL gene family and the evolutionary origins of the master cell-type regulatory gene, regA, in Volvox carteri.
Article in Journal of molecular evolution, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 42 citations in OpenAlex.
- Functional analysis of regA paralog rlsD in Volvox carteri.The Plant journal : for cell and molecular biology · 2024Article
- The Genetics of Fitness Reorganization during the Transition to Multicellularity: The VolvocineGenes · 2023Review
- A personal cost of cheating can stabilize reproductive altruism during the early evolution of clonal multicellularity.Biology letters · 2022Article
- Genome sequencing of the multicellular alga Astrephomene provides insights into convergent evolution of germ-soma differentiation.Scientific reports · 2021Article
- Long-term acclimation to cadmium exposure reveals extensive phenotypic plasticity in Chlamydomonas.Plant physiology · 2021Article
- The genetic basis for the evolution of soma: mechanistic evidence for the co-option of a stress-induced gene into a developmental master regulator.Proceedings. Biological sciences · 2020Article
- Volvox and volvocine green algae.EvoDevo · 2020Review
- Independent evolution of complex development in animals and plants: deep homology and lateral gene transfer.Development genes and evolution · 2019Article
- Cell-Type Transcriptomes of the Multicellular Green AlgaG3 (Bethesda, Md.) · 2018Article
- Whole transcriptome RNA-Seq analysis reveals extensive cell type-specific compartmentalization in Volvox carteri.BMC biology · 2017Article
- Genetic basis for soma is present in undifferentiated volvocine green algae.Journal of evolutionary biology · 2017Article
- Volvox: A simple algal model for embryogenesis, morphogenesis and cellular differentiation.Developmental biology · 2016Review
- Identification and Characterization of a cis-Regulatory Element for Zygotic Gene Expression in Chlamydomonas reinhardtii.G3 (Bethesda, Md.) · 2016Article
- The Gonium pectorale genome demonstrates co-option of cell cycle regulation during the evolution of multicellularity.Nature communications · 2016Article
- Dynamic Changes in the Transcriptome and Methylome of Chlamydomonas reinhardtii throughout Its Life Cycle.Plant physiology · 2015Article
- Green algae and the origins of multicellularity in the plant kingdom.Cold Spring Harbor perspectives in biology · 2014Review
- Transcriptome-wide profiling and expression analysis of transcription factor families in a liverwort, Marchantia polymorpha.BMC genomics · 2013Article
- Evolution of reproductive development in the volvocine algae.Sexual plant reproduction · 2011Review
- Genome-wide phylogenetic comparative analysis of plant transcriptional regulation: a timeline of loss, gain, expansion, and correlation with complexity.Genome biology and evolution · 2010Article
- PlnTFDB: updated content and new features of the plant transcription factor database.Nucleic acids research · 2010Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
Chlamydomonas reinhardtii, Volvox carteri, and their relatives in the family Volvocaceae provide an excellent opportunity for studying how multicellular organisms with differentiated cell types evolved from unicellular ancestors. While C. reinhardtii is unicellular, V. carteri is multicellular with two cell types, one of which resembles C. reinhardtii cytologically but is terminally differentiated. Maintenance of this "somatic cell" fate is controlled by RegA, a putative transcription factor. We recently showed that RegA shares a conserved region with several predicted V. carteri and C. reinhardtii proteins and that this region, the VARL domain, is likely to include a DNA-binding SAND domain. As the next step toward understanding the evolutionary origins of the regA gene, we analyzed the genome sequences of C. reinhardtii and V. carteri to identify additional genes with the potential to encode VARL domain proteins. Here we report that the VARL gene family, which consists of 12 members in C. reinhardtii and 14 in V. carteri, has experienced a complex evolutionary history in which members of the family have been both gained and lost over time, although several pairs of potentially orthologous genes can still be identified. We find that regA is part of a tandem array of four VARL genes in V. carteri but that a similar array is absent in C. reinhardtii. Most importantly, our phylogenetic analysis suggests that a proto-regA gene was present in a common unicellular ancestor of V. carteri and C. reinhardtii and that this gene was lost in the latter lineage.
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