ArticleProstate cancer and prostatic diseases2008
Differential gene expression in the peripheral zone compared to the transition zone of the human prostate gland.
Article in Prostate cancer and prostatic diseases, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Stromal FOXF2 suppresses prostate cancer progression and metastasis by enhancing antitumor immunity.Nature communications · 2022Article
- Prostate zones and cancer: lost in transition?Nature reviews. Urology · 2022Review
- Specific spatial distribution patterns of tumor foci are associated with a low risk of biochemical recurrence in pT2pN0R0 prostate cancer.World journal of urology · 2021Article
- Genomic analysis of benign prostatic hyperplasia implicates cellular re-landscaping in disease pathogenesis.JCI insight · 2019Article
- Genetic algorithm based cancerous gene identification from microarray data using ensemble of filter methods.Medical & biological engineering & computing · 2019Article
- Article
- LINE-1 methylation status in prostate cancer and non-neoplastic tissue adjacent to tumor in association with mortality.Epigenetics · 2017Article
- TMPRSS2-ERG rearrangement in dominant anterior prostatic tumours: incidence and correlation with ERG immunohistochemistry.Histopathology · 2013Article
- Differences in microRNA expression during tumor development in the transition and peripheral zones of the prostate.BMC cancer · 2013Article
- The differential effects of prostate stromal cells derived from different zones on prostate cancer epithelial cells under the action of sex hormones.Asian journal of andrology · 2011Article
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gene expression profiles may lend insight into whether prostate adenocarcinoma (CaP) predominantly occurs in the peripheral zone (PZ) compared to the transition zone (TZ). From human prostates, tissue sets consisting of PZ and TZ were isolated to investigate whether there is a differential level of gene expression between these two regions of this gland. Gene expression profiling using Affymetrix Human Genome U133 plus 2.0 arrays coupled with quantitative real-time reverse transcriptase-PCR was employed. Genes associated with neurogenesis, signal transduction, embryo implantation and cell adhesion were found to be expressed at a higher level in the PZ. Those overexpressed in the TZ were associated with neurogenesis development, signal transduction, cell motility and development. Whether such differential gene expression profiles may identify molecular mechanisms responsible for susceptibility to CaP remains to be ascertained.
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