Evidence map›Paper›PMID 17646325›Full record

ArticleBioinformatics (Oxford, England)2007

Manual curation is not sufficient for annotation of genomic databases.

William A Baumgartner, K Bretonnel Cohen, Lynne M Fox, George Acquaah-Mensah, Lawrence Hunter

Abstract read
In one paragraph

Article in Bioinformatics (Oxford, England), 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 122 papers.

0numbers the graph read from it
0cells of the map it votes in
122citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

122 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. New reasons for biologists to write with a formal language.Database : the journal of biological databases and curation · 2022
    Article
  10. AnthraxKP: a knowledge graph-based, Anthrax Knowledge Portal mined from biomedical literature.Database : the journal of biological databases and curation · 2022
    Article
  11. Article
  12. Article
  13. Review
  14. Contextualized Protein-Protein Interactions.Patterns (New York, N.Y.) · 2021
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Constructing knowledge graphs and their biomedical applications.Computational and structural biotechnology journal · 2020
    Review
  20. Article

62 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

William A BaumgartnerCenter for Computational Pharmacology, University of Colorado School of Medicine, USA.
K Bretonnel Cohen
Lynne M Fox
George Acquaah-Mensah
Lawrence Hunter

Funding

Technology Development for a MolBio Knowledge-BaseR01LM008111 · NLM · UNIVERSITY OF COLORADO DENVER · PI HUNTER, LAWRENCE E · 2004 to 2021
$9.7M
NLM NIH HHS R01 LM008111NLM NIH HHS R01-LM008111
6 · The paper itself

Abstract

motivationKnowledge base construction has been an area of intense activity and great importance in the growth of computational biology. However, there is little or no history of work on the subject of evaluation of knowledge bases, either with respect to their contents or with respect to the processes by which they are constructed. This article proposes the application of a metric from software engineering known as the found/fixed graph to the problem of evaluating the processes by which genomic knowledge bases are built, as well as the completeness of their contents.

resultsWell-understood patterns of change in the found/fixed graph are found to occur in two large publicly available knowledge bases. These patterns suggest that the current manual curation processes will take far too long to complete the annotations of even just the most important model organisms, and that at their current rate of production, they will never be sufficient for completing the annotation of all currently available proteomes.

Indexed as

Databases, ProteinChromosome MappingDocumentationGenomicsProteinsSequence Analysis, ProteinProteins

Identifiers

PMID17646325
PMCPMC2516305

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.