ReviewThe Lancet. Infectious diseases2007
Innate immunogenetics: a tool for exploring new frontiers of host defence.
Review in The Lancet. Infectious diseases, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it, 83 citations in OpenAlex.
- Association between interleukin-10 polymorphisms and sepsis: a meta-analysis.Epidemiology and infection · 2015Pooled it
- p53-responsive TLR8 SNP enhances human innate immune response to respiratory syncytial virus.The Journal of clinical investigation · 2019Trial
- Genomic evidence for shared common ancestry of East African hunting-gathering populations and insights into local adaptation.Proceedings of the National Academy of Sciences of the United States of America · 2019Trial
- Decoding Host-Pathogen Dynamics inAntibiotics (Basel, Switzerland) · 2026Review
- Role of Viral Infections in the Pathogenesis of Sjögren's Syndrome: Different Characteristics of Epstein-Barr Virus and HTLV-1.Journal of clinical medicine · 2020Review
- Formulation and preclinical evaluation of a toll-like receptor 7/8 agonist as an anti-tumoral immunomodulator.Journal of controlled release : official journal of the Controlled Release Society · 2019Article
- Polymorphisms in Receptors Involved in Opsonic and Nonopsonic Phagocytosis, and Correlation with Risk of Infection in Oncohematology Patients.Infection and immunity · 2018Article
- Risk stratification and immunogenetic risk for infections following stem cell transplantation.Virulence · 2016Review
- Functional polymorphisms of macrophage migration inhibitory factor as predictors of morbidity and mortality of pneumococcal meningitis.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Molecular characterization and analysis of TLR-1 in rabbit tissues.Central-European journal of immunology · 2016Article
- Rhesus Negative Woman Transfused With Rhesus Positive Blood: Subsequent Normal Pregnancy Without Anti D production.Ghana medical journal · 2015Article
- Host genetics of invasive Aspergillus and Candida infections.Seminars in immunopathology · 2015Review
- Lack of association between FOXO1 polymorphisms and bacteremia.International journal of clinical and experimental medicine · 2015Article
- Group A Escherichia coli-related purpura fulminans: an unusual manifestation due to an unusual strain?Journal of clinical microbiology · 2014Article
- Genetic polymorphisms and sepsis in premature neonates.PloS one · 2014Article
- Targeting toll-like receptors: promising therapeutic strategies for the management of sepsis-associated pathology and infectious diseases.Frontiers in immunology · 2013Review
- Contrasted evolutionary histories of two Toll-like receptors (Tlr4 and Tlr7) in wild rodents (MURINAE).BMC evolutionary biology · 2013Article
- Retroviral infections in sheep and goats: small ruminant lentiviruses and host interaction.Viruses · 2013Review
- A hemocyte gene expression signature correlated with predictive capacity of oysters to survive Vibrio infections.BMC genomics · 2012Article
- Systems biology applied to vaccine and immunotherapy development.BMC systems biology · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The discovery of innate immune genes, such as those encoding Toll-like receptors (TLRs), nucleotide-binding oligomerisation domain-like receptors (NLRs), and related signal-transducing molecules, has led to a substantial improvement of our understanding of innate immunity. Recent immunogenetic studies have associated polymorphisms of the genes encoding TLRs, NLRs, and key signal-transducing molecules, such as interleukin-1 receptor-associated kinase 4 (IRAK4), with increased susceptibility to, or outcome of, infectious diseases. With the availability of high-throughput genotyping techniques, it is becoming increasingly evident that analyses of genetic polymorphisms of innate immune genes will further improve our knowledge of the host antimicrobial defence response and help in identifying individuals who are at increased risk of life-threatening infections. This is likely to open new perspectives for the development of diagnostic, predictive, and preventive management strategies to combat infectious diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.