ArticleClinical and experimental immunology2007
Relationship of periodontal infection to serum antibody levels to periodontopathic bacteria and inflammatory markers in periodontitis patients with coronary heart disease.
Article in Clinical and experimental immunology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 70 citations in OpenAlex.
- Increased Production of Angiopoietin-like Protein 2 in a Ligature- and LPS-Induced Periodontitis Mouse Model May Promote Colorectal Tumor Progression.Journal of clinical medicine · 2026Article
- Serum cytokines in periodontal diseases.Periodontology 2000 · 2025Review
- Periodontal inflamed surface area is associated with hs-CRP in septuagenarian Japanese adults in cross-sectional findings from the SONIC study.Scientific reports · 2021Article
- Serum immunoglobulin G antibody titer to Fusobacterium nucleatum is associated with unfavorable outcome after stroke.Clinical and experimental immunology · 2020Article
- Serum IgG titers against periodontal pathogens are associated with cerebral hemorrhage growth and 3-month outcome.PloS one · 2020Article
- Serum IgG titers to periodontal pathogens predict 3-month outcome in ischemic stroke patients.PloS one · 2020Article
- Levels of Pro and Anti-inflammatory Citokynes and C-Reactive Protein in Patients with Chronic Periodontitis Submitted to Nonsurgical Periodontal TreatmentAsian Pacific journal of cancer prevention : APJCP · 2018Article
- Aggravation of collagen-induced arthritis by orally administered Porphyromonas gingivalis through modulation of the gut microbiota and gut immune system.Scientific reports · 2017Article
- Analysis of the relationship between periodontal disease and atherosclerosis within a local clinical system: a cross-sectional observational pilot study.Odontology · 2015Observational
- Comparative study of abdominal and thoracic aortic aneurysms: their pathogenesis and a gingival fibroblasts-based ex vivo treatment.SpringerPlus · 2015Article
- [More] evidence to support oral health promotion services targeted to smokers calling tobacco quitlines in the United States.BMC public health · 2013Article
- Factors related to tooth loss among community-dwelling middle-aged and elderly Japanese men.Journal of epidemiology · 2013Article
- Serum antibodies to periodontal pathogens are a risk factor for Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2012Article
- Relationship between periodontitis-related antibody and frequent exacerbations in chronic obstructive pulmonary disease.PloS one · 2012Article
- Bacterial invasion of vascular cell types: vascular infectology and atherogenesis.Future cardiology · 2012Review
- Chronic oral infection with Porphyromonas gingivalis accelerates atheroma formation by shifting the lipid profile.PloS one · 2011Article
- Lipoproteins and lipoprotein metabolism in periodontal disease.Clinical lipidology · 2010Article
- Review
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several reports have demonstrated a possible association of periodontal infections with coronary heart disease (CHD) by elevated antibody titre to periodontopathic bacteria in CHD patients compared with non-diseased controls. Although each periodontopathic bacterium may vary in virulence for periodontitis and atherosclerosis, antibody response to multiple bacteria in CHD patients has not been understood fully. Therefore, serum levels of antibody to 12 periodontopathic bacteria together with other atherosclerotic risk markers were compared among 51 patients with CHD, 55 patients with moderate to severe chronic periodontitis and 37 healthy individuals. The antibody response was the most prevalent for Porphyromonas gingivalis, a major causative organism, in CHD as well as periodontitis patients. However, antibody positivity was different between CHD and periodontitis if the response was analysed for two different strains of P. gingivalis, namely FDC381 and Su63. While periodontitis patients were positive for both P. gingivalis FDC381 and Su63, a high frequency of antibody positivity for P. gingivalis Su63 but not for FDC381 was observed in CHD patients. The results indicate that the presence of particular periodontopathic bacteria with high virulence may affect atherogenesis. Identifying the virulence factors of P. gingivalis Su63 may gain insight into the new therapeutic modality for infection-induced deterioration of atherosclerosis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.