ArticleEpilepsia2007
Preserved proper naming following left anterior temporal lobectomy is associated with early age of seizure onset.
Article in Epilepsia, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 39 citations in OpenAlex.
- Multimodality word-finding distinctions in cortical stimulation mapping.Neurosurgery · 2013Trial
- Object naming after epilepsy surgery in the dominant left temporal lobe: risk factors, time course and long-term outcome.Journal of neurology, neurosurgery, and psychiatry · 2025Article
- Lesion and lesion network localization of dysnomia after epilepsy surgery.Brain : a journal of neurology · 2025Article
- Age of epilepsy onset as modulating factor for naming deficit after epilepsy surgery: a voxel-based lesion-symptom mapping study.Scientific reports · 2023Article
- Knowledge of language function and underlying neural networks gained from focal seizures and epilepsy surgery.Brain and language · 2019Review
- Nomograms to predict naming decline after temporal lobe surgery in adults with epilepsy.Neurology · 2018Article
- Observational
- Beta modulation reflects name retrieval in the human anterior temporal lobe: an intracranial recording study.Journal of neurophysiology · 2016Article
- Article
- Atypical language organization in temporal lobe epilepsy revealed by a passive semantic paradigm.BMC neurology · 2014Article
- Mapping the temporal pole with a specialized electrode array: technique and preliminary results.Physiological measurement · 2014Article
- Famous face identification in temporal lobe epilepsy: support for a multimodal integration model of semantic memory.Cortex; a journal devoted to the study of the nervous system and behavior · 2013Article
- The neurobiology of cognitive disorders in temporal lobe epilepsy.Nature reviews. Neurology · 2011Review
- The selectivity and functional connectivity of the anterior temporal lobes.Cerebral cortex (New York, N.Y. : 1991) · 2010Article
- Sex-related functional asymmetry of the amygdala: preliminary evidence using a case-matched lesion approach.Neurocase · 2009Article
- Category-specific recognition and naming deficits following resection of a right anterior temporal lobe tumor in a patient with atypical language lateralization.Cortex; a journal devoted to the study of the nervous system and behavior · 2009Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
purposeAnterior temporal lobectomy (ATL) is an effective surgical option for managing pharmacoresistant temporal lobe epilepsy. Many patients with left ATL develop postsurgical difficulties with proper name retrieval, although curiously, some patients have entirely intact proper naming following left ATL. Here, we tested the hypothesis that early age of seizure onset would be a reliable factor "protecting" patients from developing proper naming defects following left ATL.
methodsProper naming of unique persons (Famous Faces Test, 155 items) and places (Landmark Test, 65 items) was measured in 23 patients who had undergone left ATL for pharmacoresistant epilepsy. Data were collected for a number of variables, including age of seizure onset, age at surgery, handedness, IQ, and seizure outcome. The patients were sorted into two groups based on proper naming performance: (1) Unimpaired: 7 patients performed normally on both the Faces and Landmark tests; (2) Impaired: 16 patients performed abnormally on one or both of the tests.
resultsIn support of our hypothesis, the Unimpaired group had a significantly earlier age of seizure onset (M = 2.1 years) than the Impaired group (M = 15.1 years). Moreover, a correlation analysis indicated a strong association between age of seizure onset and naming outcome (R =-0.569). The groups were comparable (and statistically indistinguishable) on nearly all other variables.
conclusionsThese findings document the importance of age of seizure onset in predicting proper naming outcome following left ATL (with earlier being better), and extend understanding of brain reorganization and plasticity.
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