ReviewCurrent opinion in biotechnology2007
Progress in computational protein design.
Review in Current opinion in biotechnology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 73 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
73 citing papers in PubMed.
- Entropy quantum computing for fixed-backbone protein design.Scientific reports · 2026Article
- Enriching stabilizing mutations through automated analysis of molecular dynamics simulations using BoostMut.Protein science : a publication of the Protein Society · 2025Article
- A survey of generative AI for de novo drug design: new frontiers in molecule and protein generation.Briefings in bioinformatics · 2024Article
- A Survey of Deep Learning Methods for Estimating the Accuracy of Protein Quaternary Structure Models.Biomolecules · 2024Review
- AbFlex: designing antibody complementarity determining regions with flexible CDR definition.Bioinformatics (Oxford, England) · 2024Article
- A novel computationally engineered collagenase reduces the force required for tooth extraction in an ex-situ porcine jaw model.Journal of biological engineering · 2023Article
- A gated graph transformer for protein complex structure quality assessment and its performance in CASP15.Bioinformatics (Oxford, England) · 2023Article
- Protein Design Using Physics Informed Neural Networks.Biomolecules · 2023Article
- Research progress on unique paratope structure, antigen binding modes, and systematic mutagenesis strategies of single-domain antibodies.Frontiers in immunology · 2022Review
- Protein Assembly by Design.Chemical reviews · 2021Review
- Current Status of Mining, Modification, and Application of Cellulases in Bioactive Substance Extraction.Current issues in molecular biology · 2021Review
- A Framework for Implementing Metaheuristic Algorithms Using Intercellular Communication.Frontiers in bioengineering and biotechnology · 2021Article
- Antibody Structure and Function: The Basis for Engineering Therapeutics.Antibodies (Basel, Switzerland) · 2019Review
- Experimentally guided computational antibody affinity maturation with de novo docking, modelling and rational design.PLoS computational biology · 2019Article
- DisruPPI: structure-based computational redesign algorithm for protein binding disruption.Bioinformatics (Oxford, England) · 2018Article
- Ofatumumab Monoclonal Antibody Affinity Maturation Through in silico ModelingIranian biomedical journal · 2018Article
- CATS (Coordinates of Atoms by Taylor Series): protein design with backbone flexibility in all locally feasible directions.Bioinformatics (Oxford, England) · 2017Article
- A critical analysis of computational protein design with sparse residue interaction graphs.PLoS computational biology · 2017Article
- Parallel Computational Protein Design.Methods in molecular biology (Clifton, N.J.) · 2017Article
- Adding energy minimization strategy to peptide-design algorithm enables better search for RNA-binding peptides: Redesigned λ N peptide binds boxB RNA.Journal of computational chemistry · 2016Article
13 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Current progress in computational structure-based protein design is reviewed in the areas of methodology and applications. Foundational advances include new potential functions, more efficient ways of computing energetics, flexible treatments of solvent, and useful energy function approximations, as well as ensemble-based approaches to scoring designs for inclusion of entropic effects, improvements to guaranteed and to stochastic search techniques, and methods to design combinatorial libraries for screening and selection. Applications include new approaches and successes in the design of specificity for protein folding, binding, and catalysis, in the redesign of proteins for enhanced binding affinity, and in the application of design technology to study and alter enzyme catalysis. Computational protein design continues to mature and advance.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.