ArticleBrain, behavior, and immunity2008
Positive psychosocial factors and NKT cells in ovarian cancer patients.
Article in Brain, behavior, and immunity, 2008. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 68 citations in OpenAlex.
- Bibliometric and visual analysis of chronic stress in cancer research from 2014 to 2024.Discover oncology · 2025Article
- Exploring the status of online social support for older adults with cancer: a scoping review protocol.BMJ open · 2024Article
- Effects of Psychological Stress on Multiple SclerosisCNS & neurological disorders drug targets · 2024Review
- Stress and cancer: The mechanisms of immune dysregulation and management.Frontiers in immunology · 2022Review
- Social Environment Ameliorates Behavioral and Immune Impairments in Tyrosine Hydroxylase Haploinsufficient Female Mice.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2021Article
- Social support for older adults with cancer: Young International Society of Geriatric Oncology review paper.Journal of geriatric oncology · 2020Review
- The impact of psychosocial stress and stress management on immune responses in patients with cancer.Cancer · 2019Review
- Neuroendocrine Regulation of Tumor-Associated Immune Cells.Frontiers in oncology · 2019Review
- Observational
- Perception and fulfillment of cancer patients' nursing professional social support needs: from the health care personnel point of view.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2014Article
- Biobehavioral influences on cancer progression.Immunology and allergy clinics of North America · 2011Review
- Direct and buffering effects of social support among gynecologic cancer survivors.Annals of behavioral medicine : a publication of the Society of Behavioral Medicine · 2010Article
- Norepinephrine upregulates VEGF, IL-8, and IL-6 expression in human melanoma tumor cell lines: implications for stress-related enhancement of tumor progression.Brain, behavior, and immunity · 2009Article
- Recurrence of Breast Cancer After Primary Treatment: A Matched Comparison Study of Disease-Free Survival in Women Who Do and Do Not Receive Adjunctive Naturopathic Oncology Care.Integrative cancer therapiesArticle
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Psychosocial factors are known to be associated with properties of both NK cells and T cells in cancer patients. Less is known about the relationship between psychosocial factors and NKT cells, a rare group of lymphocytes that have known relevance for tumor control. We examined four psychosocial factors and percentage and number of CD3+CD56+ NKT cells, CD3-CD56+ NK cells, and CD3+CD56- T cells in peripheral blood lymphocytes (PBL), ascites, and tumor of 35 ovarian cancer patients and 28 patients with benign pelvic masses. Patients awaiting surgery for a suspected cancerous mass completed questionnaires and gave a pre-surgical blood sample. Ascites and tumor were taken during surgery. After lymphocyte isolation, subpopulations were analyzed by flow cytometry. Benign and cancer patients did not differ on PBL subpopulations. Among cancer patients, NKT cell percentage was significantly higher in tumor and ascites than in PBL; T cell percentage was significantly higher in PBL than tumor. NKT, NK, and T cell number were significantly higher in peripheral blood than in ascites. Positive reframing was related to significantly higher NKT cell percentage and number in PBL. Social support was related to significantly higher NKT cell percentage in tumor. Vigor was related to significantly higher NKT cell percentage in PBL. Total mood disturbance was not related to NKT cell percentage or number. No significant relationships were found between psychosocial factors and NK cell percentage and number and T cell percentage and number. Given the anti-tumor activity of CD3+CD56+ cells, these relationships may have relevance for cancer control.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.