ReviewNeurochemistry international
3beta-HSD activates DHEA in the songbird brain.
Review in Neurochemistry international. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 51 citations in OpenAlex.
- Dehydroepiandrosterone (DHEA) as a tool for conservation.Environmental monitoring and assessment · 2026Review
- Dehydroepiandrosterone (DHEA) increases undirected singing behavior and alters dopaminergic regulation of undirected song in non-breeding male European starlings (Frontiers in endocrinology · 2023Article
- A Teleost Fish Model to Understand Hormonal Mechanisms of Non-breeding Territorial Behavior.Frontiers in endocrinology · 2020Review
- 3β-HSD expression in the CNS of a manakin and finch.General and comparative endocrinology · 2018Article
- Brain-Derived Steroids, Behavior and Endocrine Conflicts Across Life History Stages in Birds: A Perspective.Frontiers in endocrinology · 2018Article
- Steroid Transport, Local Synthesis, and Signaling within the Brain: Roles in Neurogenesis, Neuroprotection, and Sexual Behaviors.Frontiers in neuroscience · 2018Review
- A Quantification of the Injury-Induced Changes in Central Aromatase, Oestrogenic Milieu and Steroid Receptor Expression in the Zebra Finch.Journal of neuroendocrinology · 2016Article
- The agonistic adrenal: melatonin elicits female aggression via regulation of adrenal androgens.Proceedings. Biological sciences · 2015Article
- Sex, estradiol, and spatial memory in a food-caching corvid.Hormones and behavior · 2015Article
- Contextual modulation of social and endocrine correlates of fitness: insights from the life history of a sex changing fish.Frontiers in neuroscience · 2015Review
- Hormones and the neuromuscular control of courtship in the golden-collared manakin (Manacus vitellinus).Frontiers in neuroendocrinology · 2013Review
- Endoplasmic reticulum stress mediating downregulated StAR and 3-beta-HSD and low plasma testosterone caused by hypoxia is attenuated by CPU86017-RS and nifedipine.Journal of biomedical science · 2012Article
- DHEA and estradiol levels in brain, gonads, adrenal glands, and plasma of developing male and female European starlings.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2011Article
- Non-stereo-selective cytosolic human brain tissue 3-ketosteroid reductase is refractory to inhibition by AKR1C inhibitors.Biochimica et biophysica acta · 2010Article
- Aggressive interactions rapidly increase androgen synthesis in the brain during the non-breeding season.Hormones and behavior · 2010Article
- Corticosterone and dehydroepiandrosterone in songbird plasma and brain: effects of season and acute stress.The European journal of neuroscience · 2009Article
- Synergistic effects of dehydroepiandrosterone and fluoxetine on proliferation of progenitor cells in the dentate gyrus of the adult male rat.Neuroscience · 2009Article
- Dehydroepiandrosterone and corticosterone are regulated by season and acute stress in a wild songbird: jugular versus brachial plasma.Endocrinology · 2008Article
- Rapid estrogen regulation of DHEA metabolism in the male and female songbird brain.Journal of neurochemistry · 2008Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Dehydroepiandrosterone (DHEA) is an abundant circulating prohormone in humans, with a variety of reported actions on central and peripheral tissues. Despite its abundance, the functions of DHEA are relatively unknown because common animal models (laboratory rats and mice) have very low DHEA levels in the blood. Over the past decade, we have obtained considerable evidence from avian studies demonstrating that (1) DHEA is an important circulating prohormone in songbirds and (2) the enzyme 3beta-hydroxysteroid dehydrogenase/isomerase (3beta-HSD), responsible for converting DHEA into a more active androgen, is expressed at high levels in the songbird brain. Here, we first review biochemical and molecular studies demonstrating the widespread activity and expression of 3beta-HSD in the adult and developing songbird brain. Studies examining neural 3beta-HSD activity show effects of sex, stress, and season that are region-specific. Second, we review studies showing seasonal and stress-related changes in circulating DHEA in captive and wild songbird species. Third, we describe evidence that DHEA treatment can stimulate song behavior and the growth of neural circuits controlling song behavior. Importantly, brain 3beta-HSD and aromatase can work in concert to locally metabolize DHEA into active androgens and estrogens, which are critical for controlling behavior and robust adult neuroplasticity in songbirds. DHEA is likely secreted by the avian gonads and/or adrenals, as is the case in humans, but DHEA may also be synthesized de novo in the songbird brain from cholesterol or other precursors. Irrespective of its source, DHEA seems to be an important prohormone in songbirds, and 3beta-HSD is a key enzyme in the songbird brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.