ArticleBiochimica et biophysica acta2007
Characterization of prostaglandin E2 generation through the cyclooxygenase (COX)-2 pathway in human neutrophils.
Article in Biochimica et biophysica acta, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 62 citations in OpenAlex.
- Inhibition of COX-2-Mediated Arachidonic Acid Metabolism by FGF21-PPARα Axis Alleviates Liver Steatosis.MedComm · 2026Article
- Oral Recombinant Human Collagen III Protects Gastric Mucosa via G-Quadruplex-Mediated Activation of the Pla2g4a-Prostaglandin Axis.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Dual species transcriptomics reveals conserved metabolic and immunologic processes in interactions between human neutrophils and Neisseria gonorrhoeae.PLoS pathogens · 2024Article
- Pharmacological evidence that the inhibitory effects of prostaglandin E2 are mediated by the EP2 and EP4 receptors in human neutrophils.Journal of leukocyte biology · 2024Article
- The impact of trauma relevant concentrations of prostaglandin EFrontiers in immunology · 2024Article
- The emerging role for metabolism in fueling neutrophilic inflammation.Immunological reviews · 2023Review
- The Role of Neutrophils in Pregnancy, Term and Preterm Labour.Life (Basel, Switzerland) · 2022Review
- A proprietary herbal extract titred in verbascoside and aucubin suppresses lipopolysaccharide-stimulated expressions of cyclooxygenase-2 in human neutrophils.Central-European journal of immunology · 2020Article
- Glial interleukin-1β upregulates neuronal sodium channel 1.7 in trigeminal ganglion contributing to temporomandibular joint inflammatory hypernociception in rats.Journal of neuroinflammation · 2018Article
- Transitory presence of myeloid-derived suppressor cells in neonates is critical for control of inflammation.Nature medicine · 2018Article
- Hemodynamic force triggers rapid NETosis within sterile thrombotic occlusions.Journal of thrombosis and haemostasis : JTH · 2018Article
- Chitosan-microcapsulated insulin alleviates mesenteric microcirculation dysfunction via modulating COX-2 and VCAM-1 expression in rats with diabetes mellitus.International journal of nanomedicine · 2018Article
- Inhibition of microsomal prostaglandin E-synthase-1 (mPGES-1) selectively suppresses PGEVeterinary immunology and immunopathology · 2017Article
- A New Neolignan Derivative, Balanophonin Isolated fromBiomolecules & therapeutics · 2017Article
- Anti-inflammatory effects of cavidine in vitro and in vivo, a selective COX-2 inhibitor in LPS-induced peritoneal macrophages of mouse.Inflammation · 2015Article
- Anti-inflammatory effect of methylpenicinoline from a marine isolate of Penicillium sp. (SF-5995): inhibition of NF-κB and MAPK pathways in lipopolysaccharide-induced RAW264.7 macrophages and BV2 microglia.Molecules (Basel, Switzerland) · 2014Article
- Increased saturated fatty acids in obesity alter resolution of inflammation in part by stimulating prostaglandin production.Journal of immunology (Baltimore, Md. : 1950) · 2013Article
- Pharmacological approaches to regulate neutrophil activity.Seminars in immunopathology · 2013Review
- Article
- Oncostatin M decreases interleukin-1 β secretion by human synovial fibroblasts and attenuates an acute inflammatory reaction in vivo.Journal of cellular and molecular medicine · 2012Article
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Authors and funding
12 authors at 4 institutions in 3 countries.
Funding
Abstract
In the present study, we characterized the generation of prostaglandin (PG)E2 in human neutrophils. We found that the Ca2+-dependent type IV cytosolic phospholipase A2 (cPLA2) was pivotally involved in the COX-2-mediated generation of PGE2 in response to a calcium ionophore, as determined by the use of selected PLA2 inhibitors. PGE2 biosynthesis elicited by bacterial-derived peptides or by phagocytic stimuli acting on cell surface receptors also showed to be dependent on cPLA2 activity. We then assessed metabolism of unesterified arachidonic acid (AA), and observed that PGE2 production becomes favored over that of LTB4 with higher AA concentrations. Withdrawal of calcium prevented the generation of PGE2 in response to a calcium ionophore but did not affect the up-regulation of COX-2 or its capacity to convert AA, thus limiting its implication at the level of cPLA2 activation. Of the main eicosanoids produced by neutrophils, only LTB4 was able to up-regulate COX-2 expression. Finally, the only PGE synthase isoform found in neutrophils is microsomal PGE synthase-1; it co-localized with COX-2 and its expression appeared mainly constitutive. These results highlight key differences in regulatory processes of the 5-LO and COX pathways, and enhance our knowledge at several levels in the PGE2 biosynthesis in neutrophils.
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