Trial reportIntensive care medicine2007
Limitations of computed tomographic angiography in the diagnosis of brain death.
Trial report in Intensive care medicine, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02045407 (Computed Tomography Angiography Accuracy in Brain Death Diagnosis), which is not on this map. Cited by 24 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Computed Tomography Angiography Accuracy in Brain Death Diagnosis
Who cites it
24 citing papers in PubMed, 2 syntheses or guidelines pooled it, 84 citations in OpenAlex.
- Computed tomography angiography in the diagnosis of brain death: a systematic review and meta-analysis.Neurocritical care · 2014Pooled it
- Computed tomography (CT) angiography for confirmation of the clinical diagnosis of brain death.The Cochrane database of systematic reviews · 2014Pooled it
- Can bispectral index be an early marker in the diagnosis of brain death?Acta neurologica Belgica · 2023Article
- Exclusive color-coded duplex sonography of extracranial vessels reliably confirms brain death: A prospective study.Frontiers in neurology · 2022Article
- Brain death in a vaccinated patient with COVID-19 infection.Clinical imaging · 2022Article
- The observation period after clinical brain death diagnosis according to ancillary tests: differences between supratentorial and infratentorial brain injury.Journal of neurology · 2019Observational
- Brain Computed Tomography Angiography as an Ancillary Test in the Confirmation of Brain Death.Cureus · 2017Article
- Variability in Diagnosing Brain Death at an Academic Medical Center.Neuroscience journal · 2017Article
- Revised CT angiography venous score with consideration of infratentorial circulation value for diagnosing brain death.Annals of intensive care · 2016Article
- [Angiographic procedures for determination of cessation of cerebral circulation].Der Nervenarzt · 2016Article
- Coma and cerebral imaging.SpringerPlus · 2015Article
- Computed tomographic angiography criteria in the diagnosis of brain death-comparison of sensitivity and interobserver reliability of different evaluation scales.Neuroradiology · 2014Article
- CT Angiography in the Diagnosis of Brain Death.Polish journal of radiology · 2014Review
- Confirming the brain death diagnosis using brain CT angiography: experience in Tokat State Hospital.International journal of clinical and experimental medicine · 2014Article
- Technical aids in the diagnosis of brain death: a comparison of SEP, AEP, EEG, TCD and CT angiography.Deutsches Arzteblatt international · 2012Article
- Imaging tests in determination of brain death.Neuroradiology · 2010Article
- CT angiography for brain death diagnosis.AJNR. American journal of neuroradiology · 2009Article
- Pitfalls in the diagnosis of brain death.Neurocritical care · 2009Article
- Diagnosing brain death by CT perfusion and multislice CT angiography.Neurocritical care · 2009Article
- Brain death: what's in a name?Intensive care medicine · 2008Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the accuracy of cerebral computed tomographic angiography (CT-a) for the diagnosis of brain death (BD). DESIGN AND
settingProspective observational study in intensive care units. PATIENTS: Twenty-one clinically BD patients enrolled over 12 months. MEASUREMENTS AND
resultsAll clinically BD patients were evaluated by electroencephalography (EEG) and CT-a after exclusion of hypothermia and drug intoxication. Data collected included: demographic characteristics, cause of BD, delay between in-hospital admission and BD diagnosis and between EEG and CT-a, occurrence of cardiac arrest, administration of vasoactive agents, results of EEG and CT-a. We evaluated the sensitivity of EEG and CT-a and their agreement. Groups were compared according to BD diagnosis by EEG and CT-a (E+C+), or only by EEG (E+C(-)). Statistical analysis were performed by Mann-Whitney test and Fisher's exact test. BD was confirmed by EEG in all cases (sensitivity 100%) whereas only 11 patients of 21 had no cerebral perfusion during CT-a (sensitivity 52.4%). No agreement was documented between EEG and CT-a for the diagnosis of BD (kappa = 0). Patients' characteristics did not differ between E+C+ and E+C(-) groups. In the E+C(-) group arterial opacification was observed in 100% of patients, but opacification of the internal cerebral veins was achieved in only 30%.
conclusionsIn clinically BD patients with no electroencephalographic activity CT-a documents opacification of the intracerebral vessels in a significant percentage of the cases. Therefore CT-a cannot be recommended as a means of BD diagnosis.
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