ArticleEuropean journal of applied physiology2007
Impact of repeated bouts of eccentric exercise on myogenic gene expression.
Article in European journal of applied physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 54 citations in OpenAlex.
- Trial
- Comparable endocrine and neuromuscular adaptations to variable vs. constant gravity-dependent resistance training among young women.Journal of translational medicine · 2020Trial
- Ageing is associated with diminished muscle re-growth and myogenic precursor cell expansion early after immobility-induced atrophy in human skeletal muscle.The Journal of physiology · 2013Trial
- Effects of pre-exercise feeding on serum hormone concentrations and biomarkers of myostatin and ubiquitin proteasome pathway activity.European journal of nutrition · 2013Trial
- High-intensity circuit training change serum myostatin but not myogenin in adolescents' soccer players: a quasi-experimental study.BMC sports science, medicine & rehabilitation · 2023Article
- Changes in Pre- and Post-Electroconvulsive Therapy Serum Myostatin Levels in Patients with Treatment Resistant Depression.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2019Article
- Effect of eccentric action velocity on expression of genes related to myostatin signaling pathway in human skeletal muscle.Biology of sport · 2018Article
- Effect of eccentric contraction on satellite cell activation in human vastus lateralis muscle.The journal of physiological sciences : JPS · 2015Article
- The skeletal muscle satellite cell response to a single bout of resistance-type exercise is delayed with aging in men.Age (Dordrecht, Netherlands) · 2014Article
- Single muscle fiber gene expression with run taper.PloS one · 2014Article
- Skeletal muscle as a regulator of the longevity protein, Klotho.Frontiers in physiology · 2014Article
- Role of nitric oxide in muscle regeneration following eccentric muscle contractions in rat skeletal muscle.The journal of physiological sciences : JPS · 2013Article
- Early activation of rat skeletal muscle IL-6/STAT1/STAT3 dependent gene expression in resistance exercise linked to hypertrophy.PloS one · 2013Article
- Neural adaptations to electrical stimulation strength training.European journal of applied physiology · 2011Review
- Excitation-transcription coupling in skeletal muscle: the molecular pathways of exercise.Biological reviews of the Cambridge Philosophical Society · 2011Review
- IGF-1 splice variant and IGF-1 peptide expression patterns in young and old human skeletal muscle prior to and following sequential exercise bouts.European journal of applied physiology · 2010Article
- The synergistic effect of treadmill running on stem-cell transplantation to heal injured skeletal muscle.Tissue engineering. Part A · 2010Article
- Exercise does not influence myostatin and follistatin messenger RNA expression in young women.Journal of strength and conditioning research · 2010Article
- Hormone therapy attenuates exercise-induced skeletal muscle damage in postmenopausal women.Journal of applied physiology (Bethesda, Md. : 1985) · 2009Article
- The effect of muscle loading on skeletal muscle regenerative potential: an update of current research findings relating to aging and neuromuscular pathology.American journal of physical medicine & rehabilitation · 2009Review
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Evidence indicates that repeated-bouts of eccentric exercise (EE) do not exacerbate the extent of muscle damage indices, as compared to a single-bout. We hypothesized that molecular adaptations, under repeated-bouts of EE, would include suppression of muscle repair inhibitory factors such as myostatin and up-regulation of muscle repair positive regulatory factors such as myogenic regulatory factors (MRFs). Fifteen males were recruited for this study. The exercise group (n=9) successfully completed six sets of 15 reps of maximum voluntary eccentric contractions, for six consecutive days, using a dynamometer (Multicont-II). Blood and muscle biopsy samples were obtained from each subject 1 week prior to exercise, 2 days post the first training session, and 24 h after the last training session. Gene expression levels were determined using real-time RT-PCR. Blood samples were analyzed for creatine kinase (CK) and lactate-dehydrogenase (LDH) activity. Repeated-bouts of EE induced a large down-regulation of myostatin mRNA (-73%) which persisted throughout the study. The responses of MRFs were mild. At day 3 only myogenin increased significantly (1.9 fold) while MyoD decreased by 45%. Surprisingly, at day 7, despite the presence of muscle damage indices, all MRFs returned to the pre-exercise levels. The results of the present study showed that repeated-bouts of EE, for six consecutive days, dramatically decreased Myostatin mRNA expression but impaired the expression patterns of MRFs such that, with the exception of myogenin that showed a moderate non-sustained increase, MyoD and MYf5 response was minimal.
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