ArticleGenes and immunity2007
IA-2 autoantibodies in incident type I diabetes patients are associated with a polyadenylation signal polymorphism in GIMAP5.
Article in Genes and immunity, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 44 citations in OpenAlex.
- Quantitative temporal analysis of pancreatic islet T lymphocyte and macrophage infiltration heralded by serum IgE in congenic BioBreeding (BB) Gimap5Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025Article
- Identification of Biomarkers Associated With CD4Frontiers in immunology · 2022Article
- The three as: Alternative splicing, alternative polyadenylation and their impact on apoptosis in immune function.Immunological reviews · 2021Review
- The GIMAP Family Proteins: An Incomplete Puzzle.Frontiers in immunology · 2021Review
- Alternative cleavage and polyadenylation in health and disease.Nature reviews. Genetics · 2019Review
- Loss of GTPase of immunity-associated protein 5 (Gimap5) promotes pathogenic CD4The Journal of allergy and clinical immunology · 2019Article
- Gimap5-dependent inactivation of GSK3β is required for CD4Nature communications · 2018Article
- Development of the Nonobese Diabetic Mouse and Contribution of Animal Models for Understanding Type 1 Diabetes.Pancreas · 2017Review
- Complex Selection on Human Polyadenylation Signals Revealed by Polymorphism and Divergence Data.Genome biology and evolution · 2016Article
- Non-HLA type 1 diabetes genes modulate disease risk together with HLA-DQ and islet autoantibodies.Genes and immunity · 2015Article
- GIMAP GTPase family genes: potential modifiers in autoimmune diabetes, asthma, and allergy.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Tubulin- and actin-associating GIMAP4 is required for IFN-γ secretion during Th cell differentiation.Immunology and cell biology · 2015Article
- Central role of gimap5 in maintaining peripheral tolerance and T cell homeostasis in the gut.Mediators of inflammation · 2015Review
- Generation and characterisation of mice deficient in the multi-GTPase domain containing protein, GIMAP8.PloS one · 2014Article
- Temporal induction of immunoregulatory processes coincides with age-dependent resistance to viral-induced type 1 diabetes.Genes and immunity · 2013Article
- The immune system GTPase GIMAP6 interacts with the Atg8 homologue GABARAPL2 and is recruited to autophagosomes.PloS one · 2013Article
- Alterations in polyadenylation and its implications for endocrine disease.Frontiers in endocrinology · 2013Article
- FOXO transcription factors throughout T cell biology.Nature reviews. Immunology · 2012Review
- Loss of immunological tolerance in Gimap5-deficient mice is associated with loss of Foxo in CD4+ T cells.Journal of immunology (Baltimore, Md. : 1950) · 2012Article
- BB rat Gimap gene expression in sorted lymphoid T and B cells.Life sciences · 2011Article
Corrections and comments
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Authors and funding
50 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In a large case-control study of Swedish incident type I diabetes patients and controls, 0-34 years of age, we tested the hypothesis that the GIMAP5 gene, a key genetic factor for lymphopenia in spontaneous BioBreeding rat diabetes, is associated with type I diabetes; with islet autoantibodies in incident type I diabetes patients or with age at clinical onset in incident type I diabetes patients. Initial scans of allelic association were followed by more detailed logistic regression modeling that adjusted for known type I diabetes risk factors and potential confounding variables. The single nucleotide polymorphism (SNP) rs6598, located in a polyadenylation signal of GIMAP5, was associated with the presence of significant levels of IA-2 autoantibodies in the type I diabetes patients. Patients with the minor allele A of rs6598 had an increased prevalence of IA-2 autoantibody levels compared to patients without the minor allele (OR=2.2; Bonferroni-corrected P=0.003), after adjusting for age at clinical onset (P=8.0 x 10(-13)) and the numbers of HLA-DQ A1*0501-B1*0201 haplotypes (P=2.4 x 10(-5)) and DQ A1*0301-B1*0302 haplotypes (P=0.002). GIMAP5 polymorphism was not associated with type I diabetes or with GAD65 or insulin autoantibodies, ICA, or age at clinical onset in patients. These data suggest that the GIMAP5 gene is associated with islet autoimmunity in type I diabetes and add to recent findings implicating the same SNP in another autoimmune disease.
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