ArticleAmerican journal of respiratory cell and molecular biology2007
Antigen-presenting cell population dynamics during murine silicosis.
Article in American journal of respiratory cell and molecular biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Association between interleukin gene polymorphisms and the risk of pneumoconiosis: a systematic review and meta-analysis.Frontiers in medicine · 2025Pooled it
- Immune mechanisms and novel therapies for idiopathic pulmonary fibrosis.Pharmaceutical science advances · 2024Review
- The role of inflammation in silicosis.Frontiers in pharmacology · 2024Review
- Think Beyond Particle Cytotoxicity: When Self-Cellular Components Released After Immunogenic Cell Death Explain Chronic Disease Development.Frontiers in toxicology · 2022Review
- Requisite Omega-3 HUFA Biomarker Thresholds for Preventing Murine Lupus Flaring.Frontiers in immunology · 2020Article
- Prevention of crystalline silica-induced inflammation by the anti-malarial hydroxychloroquine.Inhalation toxicology · 2019Article
- Silica Particles Mediate Phenotypic and Functional Alteration of Dendritic Cells and Induce Th2 Cell Polarization.Frontiers in immunology · 2019Article
- Dendritic cells trigger imbalance of Th1/Th2 cells in silica dust exposure rat modelRSC advances · 2018Article
- Immunity to the Dual Threat of Silica Exposure andFrontiers in immunology · 2018Review
- Role of a novel immune modulating DDR2-expressing population in silica-induced pulmonary fibrosis.PloS one · 2017Article
- Macrophage-derived MCPIP1 mediates silica-induced pulmonary fibrosis via autophagy.Particle and fibre toxicology · 2016Article
- Acute Exposure to Crystalline Silica Reduces Macrophage Activation in Response to Bacterial Lipoproteins.Frontiers in immunology · 2016Article
- Uncoupling between inflammatory and fibrotic responses to silica: evidence from MyD88 knockout mice.PloS one · 2014Article
- Role of the aryl hydrocarbon receptor (AhR) in lung inflammation.Seminars in immunopathology · 2013Review
- Chronic endotoxin exposure produces airflow obstruction and lung dendritic cell expansion.American journal of respiratory cell and molecular biology · 2012Article
- Aryl hydrocarbon receptor (AhR) regulates silica-induced inflammation but not fibrosis.Toxicological sciences : an official journal of the Society of Toxicology · 2012Article
- Toxic elements in tobacco and in cigarette smoke: inflammation and sensitization.Metallomics : integrated biometal science · 2011Review
- Critical role of MARCO in crystalline silica-induced pulmonary inflammation.Toxicological sciences : an official journal of the Society of Toxicology · 2009Article
- Differential binding of inorganic particles to MARCO.Toxicological sciences : an official journal of the Society of Toxicology · 2009Article
- CD11c+ antigen presenting cells from the alveolar space, lung parenchyma and spleen differ in their phenotype and capabilities to activate naïve and antigen-primed T cells.BMC immunology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Silicosis is an occupational lung disease resulting from the inhalation of silica particles over prolonged periods of time, which causes chronic inflammation and progressive pulmonary fibrosis. Alveolar macrophages (AM) are critical effector cells, while less is known about the role and function of pulmonary dendritic cells (DC) in silicosis. We hypothesize that a balance exists between the suppressive nature of AM and the stimulatory capacity of DC to regulate lung immunity, and that this equilibrium may be overcome by silica exposure in vivo. Our results demonstrate that in response to silica exposure, both the percent and absolute number of AM significantly decreased over time, with a concomitant significant increase in DC. Both AM and DC exhibited cellular activation in response to silica, indicated by increased expression of cell surface markers. In the absence of silica-induced AM apoptosis (TNFR 1/2-null and Gld mice), no change was observed in the percent or absolute number of either cell type. Furthermore, bone marrow-derived DC, but not bone marrow-derived macrophages, migrated from the alveoli into the lung parenchyma in response to silica, resulting in significantly increased numbers of activated T lymphocytes. Collectively, the results demonstrate that AM and DC are distinct antigen-presenting cells within the respiratory tract that respond to silica exposure in vivo in unique ways, with significant implications for immune reactivity of the lung in response to environmental pathogens.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.