ArticleAmerican journal of respiratory cell and molecular biology2007
Laminin-binding integrin alpha7 is required for contractile phenotype expression by human airway myocytes.
Article in American journal of respiratory cell and molecular biology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 55 citations in OpenAlex.
- Laminin Receptors in Peripheral Tissues: Functions Revealed by Analysis of Knockout Mice.The American journal of pathology · 2025Review
- Transgenic overexpression of α7 integrin in smooth muscle attenuates allergen-induced airway inflammation in a murine model of asthma.FASEB bioAdvances · 2022Article
- Integrins and extracellular matrix proteins modulate adipocyte thermogenic capacity.Scientific reports · 2021Article
- Integrin α7 expression is increased in asthmatic patients and its inhibition reduces Kras protein abundance in airway smooth muscle cells.Scientific reports · 2019Article
- The involvement of the laminin-integrin α7β1 signaling pathway in mechanical ventilation-induced pulmonary fibrosis.Journal of thoracic disease · 2017Article
- Integrins as Therapeutic Targets for Respiratory Diseases.Current molecular medicine · 2015Review
- Article
- Laminin drives survival signals to promote a contractile smooth muscle phenotype and airway hyperreactivity.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2013Article
- Integrin upregulation and localization to focal adhesion sites in pregnant human myometrium.Reproductive sciences (Thousand Oaks, Calif.) · 2013Article
- Development and characterization of a 3D multicell microtissue culture model of airway smooth muscle.American journal of physiology. Lung cellular and molecular physiology · 2013Article
- Motility, survival, and proliferation.Comprehensive Physiology · 2012Review
- Integrin and GPCR Crosstalk in the Regulation of ASM Contraction Signaling in Asthma.Journal of allergy · 2012Article
- Caveolin-1 is required for contractile phenotype expression by airway smooth muscle cells.Journal of cellular and molecular medicine · 2011Article
- Identification of an IFN-γ/mast cell axis in a mouse model of chronic asthma.The Journal of clinical investigation · 2011Article
- Akt activation induces hypertrophy without contractile phenotypic maturation in airway smooth muscle.American journal of physiology. Lung cellular and molecular physiology · 2011Article
- Direct evidence for functional smooth muscle myosin II in the 10S self-inhibited monomeric conformation in airway smooth muscle cells.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- MicroRNA expression in human airway smooth muscle cells: role of miR-25 in regulation of airway smooth muscle phenotype.American journal of respiratory cell and molecular biology · 2010Article
- Expression of functional leukotriene B4 receptors on human airway smooth muscle cells.The Journal of allergy and clinical immunology · 2009Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
Contractile airway smooth muscle (ASM) cells retain the ability for phenotype plasticity in response to multiple stimuli, which equips them with capacity to direct modeling and remodeling during development, and in disease states such as asthma. We have shown that endogenously expressed laminin is required for maturation of human ASM cells to a contractile phenotype, as occurs during ASM thickening in asthma. In this study, we profiled the expression of laminin-binding integrins alpha3beta1, alpha6beta1, and alpha7beta1, and tested whether they are required for laminin-induced myocyte maturation. Immunoblotting revealed that myocyte maturation induced by prolonged serum withdrawal, which was marked by the accumulation of contractile phenotype marker protein desmin, was also associated with the accumulation of alpha3A, alpha6A, and alpha7B. Flow cytometry revealed that alpha7B expression was a distinct feature of individual myocytes that acquired a contractile phenotype. siRNA knockdown of alpha7, but not alpha3 or alpha6, suppressed myocyte maturation. Thus, alpha7B is a novel marker of the contractile phenotype, and alpha7 expression is essential for human ASM cell maturation, which is a laminin-dependent process. These observations provide new insight into mechanisms that likely underpin normal development and remodeling associated with airways disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.