SynthesisAmerican journal of epidemiology2007
Head injury and amyotrophic lateral sclerosis.
Synthesis in American journal of epidemiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 136 papers, 7 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
136 citing papers in PubMed, 7 syntheses or guidelines pooled it, 271 citations in OpenAlex.
- Risk factors associated with amyotrophic lateral sclerosis based on the observational study: a systematic review and meta-analysis.Frontiers in neuroscience · 2023Pooled it
- Military service and related risk factors for amyotrophic lateral sclerosis.Acta neurologica Scandinavica · 2021Pooled it
- Is traumatic brain injury a risk factor for neurodegeneration? A meta-analysis of population-based studies.BMC neurology · 2018Pooled it
- Epidemiology of recurrent traumatic brain injury in the general population: A systematic review.Neurology · 2017Pooled it
- Meta-analytic evaluation of the association between head injury and risk of amyotrophic lateral sclerosis.European journal of epidemiology · 2017Pooled it
- Association of traumatic brain injury with subsequent neurological and psychiatric disease: a meta-analysis.Journal of neurosurgery · 2016Pooled it
- Pesticide exposure and amyotrophic lateral sclerosis.Neurotoxicology · 2012Pooled it
- Severe head injury and amyotrophic lateral sclerosis.Amyotrophic lateral sclerosis & frontotemporal degeneration · 2013Trial
- Associations of self-reported and objectively measured physical activity and amyotrophic lateral sclerosis risk.Journal of neurology, neurosurgery, and psychiatry · 2026Article
- Head trauma and environment progression of amyotrophic lateral sclerosis: long-term data from the National ALS Registry.BMJ neurology open · 2026Article
- Metal ion dyshomeostasis in neurological disorders: from pathological mechanisms to targeted neuroprotective and regenerative strategies.Frontiers in pharmacology · 2026Review
- Biofluid-based predictors of post-concussion symptoms: a narrative review of mild traumatic brain injury biomarkers.Brain communications · 2026Review
- Strenuous physical activity is associated with a younger age of amyotrophic lateral sclerosis onset in two independent cohorts.Brain communications · 2026Article
- Progression Independent of the Triggering Event in Neurologic Diseases.Neurology(R) neuroimmunology & neuroinflammation · 2025Article
- Longitudinal Assessment of Selective Motor Dysfunction in Service Members With Combat-Related Mild TBI.Military medicine · 2025Article
- Cellular and molecular mechanisms of pathological tau phosphorylation in traumatic brain injury: implications for chronic traumatic encephalopathy.Molecular neurodegeneration · 2025Review
- Head Injury and Amyotrophic Lateral Sclerosis: Population-Based Study from the National ALS Registry.Brain sciences · 2025Article
- Olfactory dysfunction with traumatic brain injury and posttraumatic-stress symptoms in post-deployed military personnel.Frontiers in neurology · 2025Article
- Aberrant protein aggregation in amyotrophic lateral sclerosis.Journal of neurology · 2024Review
- Soccer (football) and brain health.Journal of neurology · 2024Review
76 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Recent data showed that soccer players in Italy had an unusually high risk of amyotrophic lateral sclerosis (ALS) and that repeated head trauma might have contributed to this increase. The authors examined whether head injury was related to ALS risk in a case-control study of 109 New England ALS cases diagnosed in 1993-1996 and 255 matched controls. They also conducted a meta-analysis of the published literature. Overall, ever having experienced a head injury was nonsignificantly associated with a higher ALS risk. When compared with persons without a head injury, a statistically significant ALS risk elevation was found for participants with more than one head injury (odds ratio (OR) = 3.1, 95 percent confidence interval (CI): 1.2, 8.1) and patients who had had a head injury during the past 10 years (OR = 3.2, 95 percent CI: 1.0, 10.2). For participants who had had multiple head injuries with the latest occurring in the past 10 years, risk was elevated more than 11-fold. The meta-analysis also indicated a moderately elevated risk of ALS among persons with previous head injuries (OR = 1.7, 95 percent CI: 1.3, 2.2). In this study population, physical injuries to other body parts, including the trunk, arms, or legs, were not related to ALS risk. These data support the notion that head injury may increase the risk of ALS.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.