ArticleProceedings of the National Academy of Sciences of the United States of America2007
Natural polymorphism affecting learning and memory in Drosophila.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
77 citing papers in PubMed, 170 citations in OpenAlex.
- The foraging gene coordinates brain and heart networks to modulate socially cued interval timing in Drosophila.PLoS genetics · 2025Article
- What could evolve in the evolution of memory?Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Article
- Evolution of diverse (and advanced) cognitive abilities through adaptive fine-tuning of learning and chunking mechanisms.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025Article
- Multiple methods for assessing learning and memory inbioRxiv : the preprint server for biology · 2025Article
- Comparative analysis of phosphorylated proteomes between plerocercoid and adult Spirometra mansoni reveals phosphoproteomic profiles of the medical tapeworm.Parasites & vectors · 2024Article
- Adaptive phenotypic plasticity induces individual variability along a cognitive trade-off.Proceedings. Biological sciences · 2023Article
- Review
- Evolution of central neural circuits: state of the art and perspectives.Nature reviews. Neuroscience · 2022Review
- Genes Responsible for HBiomolecules · 2022Article
- Drosophila Passive Avoidance Behavior as a New Paradigm to Study Associative Aversive Learning.Journal of visualized experiments : JoVE · 2021Article
- Expression of theJournal of neurogenetics · 2021Article
- TheJournal of neurogenetics · 2021Article
- Hsp70 affects memory formation and behaviorally relevant gene expression in Drosophila melanogaster.Cell stress & chaperones · 2021Article
- Article
- Cellular and circuit mechanisms of olfactory associative learning inJournal of neurogenetics · 2020Review
- Article
- Aging and the clock: Perspective from flies to humans.The European journal of neuroscience · 2020Review
- Multiple genetic loci affect place learning and memory performance in Drosophila melanogaster.Genes, brain, and behavior · 2019Article
- Habitat and social context affect memory phenotype, exploration and covariance among these traits.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Article
- Why does the magnitude of genotype-by-environment interaction vary?Ecology and evolution · 2018Review
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Knowing which genes contribute to natural variation in learning and memory would help us understand how differences in these cognitive traits evolve among populations and species. We show that a natural polymorphism at the foraging (for) locus, which encodes a cGMP-dependent protein kinase (PKG), affects associative olfactory learning in Drosophila melanogaster. In an assay that tests the ability to associate an odor with mechanical shock, flies homozygous for one natural allelic variant of this gene (forR) showed better short-term but poorer long-term memory than flies homozygous for another natural allele (fors). The fors allele is characterized by reduced PKG activity. We showed that forR-like levels of both short-term learning and long-term memory can be induced in fors flies by selectively increasing the level of PKG in the mushroom bodies, which are centers of olfactory learning in the fly brain. Thus, the natural polymorphism at for may mediate an evolutionary tradeoff between short- and long-term memory. The respective strengths of learning performance of the two genotypes seem coadapted with their effects on foraging behavior: forR flies move more between food patches and so could particularly benefit from fast learning, whereas fors flies are more sedentary, which should favor good long-term memory.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.