ArticleProceedings of the National Academy of Sciences of the United States of America2007
A mutation in a chromosome condensin II subunit, kleisin beta, specifically disrupts T cell development.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 55 citations in OpenAlex.
- SMC2 and Condensin II Subunits Are Essential for the Development of Hematopoietic Stem and Progenitor Cells in Zebrafish.Journal of cellular physiology · 2025Article
- Epigenetic instability caused by absence of CIZ1 drives transformation during quiescence cycles.BMC biology · 2023Article
- Rapid and specific degradation of endogenous proteins in mouse models using auxin-inducible degrons.eLife · 2022Article
- Chromatin Dynamics During Entry to Quiescence and Compromised Functionality in Cancer Cells.Results and problems in cell differentiation · 2022Article
- Cancer-associated mutations in the condensin II subunit CAPH2 cause genomic instability through telomere dysfunction and anaphase chromosome bridges.Journal of cellular physiology · 2021Article
- Autosomal Recessive Primary Microcephaly: Not Just a Small Brain.Frontiers in cell and developmental biology · 2021Review
- Explore a novel function of human condensins in cellular senescence.Cell & bioscience · 2020Review
- Condensin I is required for faithful meiosis in Drosophila males.Chromosoma · 2020Article
- The abrogation of condensin function provides independent evidence for defining the self-renewing population of pluripotent stem cells.Developmental biology · 2018Article
- Mice Deficient in Nucleoporin Nup210 Develop Peripheral T Cell Alterations.Frontiers in immunology · 2018Article
- Condensin II mutation causes T-cell lymphoma through tissue-specific genome instability.Genes & development · 2016Article
- Mutations in genes encoding condensin complex proteins cause microcephaly through decatenation failure at mitosis.Genes & development · 2016Article
- Calcium mobilization is both required and sufficient for initiating chromatin decondensation during activation of peripheral T-cells.Molecular immunology · 2015Article
- Drosophila casein kinase I alpha regulates homolog pairing and genome organization by modulating condensin II subunit Cap-H2 levels.PLoS genetics · 2015Article
- Overlapping and non-overlapping functions of condensins I and II in neural stem cell divisions.PLoS genetics · 2014Article
- Function of YY1 in Long-Distance DNA Interactions.Frontiers in immunology · 2014Review
- YY1 controls Igκ repertoire and B-cell development, and localizes with condensin on the Igκ locus.The EMBO journal · 2013Article
- SCFSlimb ubiquitin ligase suppresses condensin II-mediated nuclear reorganization by degrading Cap-H2.The Journal of cell biology · 2013Article
- Functional dissection of the Drosophila melanogaster condensin subunit Cap-G reveals its exclusive association with condensin I.PLoS genetics · 2013Article
- Condensins: universal organizers of chromosomes with diverse functions.Genes & development · 2012Review
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Condensins are ubiquitously expressed multiprotein complexes that are important for chromosome condensation and epigenetic regulation of gene transcription, but whose specific roles in vertebrates are poorly understood. We describe a mouse strain, nessy, isolated during an ethylnitrosourea screen for recessive immunological mutations. The nessy mouse has a defect in T lymphocyte development that decreases circulating T cell numbers, increases their expression of the activation/memory marker CD44, and dramatically decreases the numbers of CD4(+)CD8(+) thymocytes and their immediate DN4 precursors. A missense mutation in an unusual alternatively spliced first exon of the kleisin beta gene, a member of the condensin II complex, was shown to be responsible and act in a T cell-autonomous manner. Despite the ubiquitous expression and role of condensins, kleisin beta(nes/nes) mice were viable, fertile, and showed no defects even in the parallel pathway of B cell lymphocyte differentiation. These data define a unique lineage-specific requirement for kleisin beta in mammalian T cell differentiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.