ArticleBMC physiology2007
Prolactin stimulates the proliferation of normal female cholangiocytes by differential regulation of Ca2+-dependent PKC isoforms.
Article in BMC physiology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 41 citations in OpenAlex.
- Regulators of Cholangiocyte Proliferation.Gene expression · 2017Review
- Ischemia reperfusion of the hepatic artery induces the functional damage of large bile ducts by changes in the expression of angiogenic factors.American journal of physiology. Gastrointestinal and liver physiology · 2015Article
- Women and primary biliary cirrhosis.Clinical reviews in allergy & immunology · 2015Review
- Recent advances on the mechanisms regulating cholangiocyte proliferation and the significance of the neuroendocrine regulation of cholangiocyte pathophysiology.Annals of translational medicine · 2013Review
- Role of follicle-stimulating hormone on biliary cyst growth in autosomal dominant polycystic kidney disease.Liver international : official journal of the International Association for the Study of the Liver · 2013Article
- Recent advances in the morphological and functional heterogeneity of the biliary epithelium.Experimental biology and medicine (Maywood, N.J.) · 2013Review
- Autocrine regulation of biliary pathology by activated cholangiocytes.American journal of physiology. Gastrointestinal and liver physiology · 2012Review
- Castration inhibits biliary proliferation induced by bile duct obstruction: novel role for the autocrine trophic effect of testosterone.American journal of physiology. Gastrointestinal and liver physiology · 2011Article
- Knockout of the neurokinin-1 receptor reduces cholangiocyte proliferation in bile duct-ligated mice.American journal of physiology. Gastrointestinal and liver physiology · 2011Article
- Regulation of biliary proliferation by neuroendocrine factors: implications for the pathogenesis of cholestatic liver diseases.The American journal of pathology · 2011Review
- Taurocholic acid prevents biliary damage induced by hepatic artery ligation in cholestatic rats.Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver · 2010Article
- Histamine regulation of hyperplastic and neoplastic cell growth in cholangiocytes.World journal of gastrointestinal pathophysiology · 2010Article
- Role of sex hormones in the modulation of cholangiocyte function.World journal of gastrointestinal pathophysiology · 2010Article
- Caffeic acid phenethyl ester decreases cholangiocarcinoma growth by inhibition of NF-kappaB and induction of apoptosis.International journal of cancer · 2009Article
- Follicle-stimulating hormone increases cholangiocyte proliferation by an autocrine mechanism via cAMP-dependent phosphorylation of ERK1/2 and Elk-1.American journal of physiology. Gastrointestinal and liver physiology · 2009Article
- Taurocholate feeding to bile duct ligated rats prevents caffeic acid-induced bile duct damage by changes in cholangiocyte VEGF expression.Experimental biology and medicine (Maywood, N.J.) · 2009Article
- Control of cholangiocyte adaptive responses by visceral hormones and neuropeptides.Clinical reviews in allergy & immunology · 2009Review
- Small mouse cholangiocytes proliferate in response to H1 histamine receptor stimulation by activation of the IP3/CaMK I/CREB pathway.American journal of physiology. Cell physiology · 2008Article
- Progesterone stimulates the proliferation of female and male cholangiocytes via autocrine/paracrine mechanisms.American journal of physiology. Gastrointestinal and liver physiology · 2008Article
Corrections and comments
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Authors and funding
18 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundProlactin promotes proliferation of several cells. Prolactin receptor exists as two isoforms: long and short, which activate different transduction pathways including the Ca2+-dependent PKC-signaling. No information exists on the role of prolactin in the regulation of the growth of female cholangiocytes. The rationale for using cholangiocytes from female rats is based on the fact that women are preferentially affected by specific cholangiopathies including primary biliary cirrhosis. We propose to evaluate the role and mechanisms of action by which prolactin regulates the growth of female cholangiocytes.
resultsNormal cholangiocytes express both isoforms (long and short) of prolactin receptors, whose expression increased following BDL. The administration of prolactin to normal female rats increased cholangiocyte proliferation. In purified normal female cholangiocytes, prolactin stimulated cholangiocyte proliferation, which was associated with increased [Ca2+]i levels and PKCbeta-I phosphorylation but decreased PKCalpha phosphorylation. Administration of an anti-prolactin antibody to BDL female rats decreased cholangiocyte proliferation. Normal female cholangiocytes express and secrete prolactin, which was increased in BDL rats. The data show that prolactin stimulates normal cholangiocyte growth by an autocrine mechanism involving phosphorylation of PKCbeta-I and dephosphorylation of PKCalpha.
conclusionWe suggest that in female rats: (i) prolactin has a trophic effect on the growth of normal cholangiocytes by phosphorylation of PKCbeta-I and dephosphorylation of PKCalpha; and (iii) cholangiocytes express and secrete prolactin, which by an autocrine mechanism participate in regulation of cholangiocyte proliferation. Prolactin may be an important therapeutic approach for the management of cholangiopathies affecting female patients.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.