ArticleBMC immunology2007
TSLP is involved in expansion of early thymocyte progenitors.
Article in BMC immunology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
11 citing papers in PubMed, 18 citations in OpenAlex.
- The Thymus Regeneration Paradox: The Search for Stemness in an Involuting Organ.Immunological reviews · 2026Review
- Interleukin-7 Receptor Alpha in Innate Lymphoid Cells: More Than a Marker.Frontiers in immunology · 2019Review
- A human immune system mouse model with robust lymph node development.Nature methods · 2018Article
- TGF-β type II receptor expression in thymic epithelial cells inhibits the development of Hassall's corpuscles in mice.International immunology · 2013Article
- Interleukin-7 supports survival of T-cell receptor-β-expressing CD4(-) CD8(-) double-negative thymocytes.Immunology · 2013Article
- TSLP directly impairs pulmonary Treg function: association with aberrant tolerogenic immunity in asthmatic airway.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2010Article
- Magnetic resonance imaging of radiation-induced thymic atrophy as a model for pathologic changes in acute feline immunodeficiency virus infection.Journal of feline medicine and surgery · 2009Article
- Welcome to the neighborhood: epithelial cell-derived cytokines license innate and adaptive immune responses at mucosal sites.Immunological reviews · 2008Review
- Strategies for reconstituting and boosting T cell-based immunity following haematopoietic stem cell transplantation: pre-clinical and clinical approaches.Seminars in immunopathology · 2008Review
- Gut microbiota and lipopolysaccharide content of the diet influence development of regulatory T cells: studies in germ-free mice.BMC immunology · 2008Article
- Cytokines, leptin, and stress-induced thymic atrophy.Journal of leukocyte biology · 2008Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThymic stromal derived lymphopoietin (TSLP) is preferentially and highly expressed in the thymus, but its function in T cell development is not clear.
resultsWe report here that TSLP, independently or in combination with IL-7, enhances thymopoiesis in the murine fetal thymic organ culture (FTOC) model. Furthermore, TSLP preferentially increases the number and proliferation of the (DN1 and DN2) pro-T progenitor cells, and FTOC lobes from TSLP receptor-null mice show a decreased number of these cells. Finally, DN1-DN2 cells expanded with TSLP in vitro are functional T progenitors that are able to differentiate into mature T cells in fetal or adult thymus organs.
conclusionTogether, these data suggest that TSLP plays an important role in expansion of thymocyte progenitors and may be of value for expanding T progenitor cells in vitro.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.